Cardiovascular Events, Depression, Stroke Recurrence
Conditions
Keywords
Depression, Treatment, Stroke, Myocardial infarction
Brief summary
It is not clear whether depresssion can predispose, or precipitate stroke recurrence in patients with stroke. We sought the relationship of post stroke depression with stroke recurrence.
Detailed description
A large body of evidence suggests that depression is associated with a increased risk of many chronic diseases, including hypertension, diabetes, stroke and particularly coronary heart disease. Post stroke depression (PSD) may develop as a result of vascular disease. A previous meta-analysis showed that depression significantly increased the risk of development of stroke, and this increase was probably independent of other risk factors, including hypertension and diabetes. Clarifying this issue has important implications; if depression increases the risk of development of recurrent stroke, so treating PSD might decrease the occurrence of recurrent stroke. To our knowledge there is no study attempting to clarify the relationship between PSD treatment and stroke recurrence. To fill these gap, we systematically conducted a study to assess whether PSD is associated with recurrent stroke, cardiovascular events or death. Thus, in the current study, three different arms of follow-up of patients with first-ever stroke, were used to predict the outcome over 52 weeks.
Interventions
DRUGCitalopram
Antidepressant use in patients with depression
Sponsors
Ege University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Masking description
There is no masking
Intervention model description
Three-site, prospective, nonrandomized controlled trial.
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
• Patients who met DSM-IV and V criteria for depression
Exclusion criteria
* Severe or unstable medical disorders (eg, myocardial infarction within past 3 months, end-stage cancer, decompensated cardiac failure) * Known primary neurological disorders including dementia, delirium, Parkinson disease, brain tumors, multiple sclerosis, seizure disorder * Drugs (eg, systemic steroids) * Pancreatic cancer, uncorrected hypothyroidism * Current suicidal risk * Use of psychotropic prescription or nonprescription drugs, certain hypnotics * Mini-Mental State Examination (MMSE) score of 21 or lower
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Stroke recurrence | 12 months | Standard World Health Organization definitions were used for recurrent stroke |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular Event | 12 months | Cardiovascular events were defined and recorded over the study period if they had at least one of the following: myocardial infarction; unstable angina; angina; percutaneous coronary intervention; or coronary artery bypass graft surgery. |
Countries
Turkey (Türkiye)
Outcome results
None listed