Overweight and Obesity
Conditions
Brief summary
In overweight individuals (BMI \> 27.5 kg/m2), does daily consumption of mycoprotein containing Quorn Food products lower blood cholesterol compared with daily meat/fish consumption?
Interventions
DIETARY_SUPPLEMENTQuorn Foods products
180 g mycoprotein (wet weight; corresponding to 45 g dry weight) per day (equates to approx. 215 g Quorn Foods products, depending on the product)
DIETARY_SUPPLEMENTMeat/fish products
Standard meat/fish products matched to Quorn group for protein intake
Sponsors
Marlow Foods Ltd
NIHR Exeter Clinical Research Facility
University of Exeter
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-70 years old * BMI \>27.5 kg/m2 * Non allergic to penicillin/mycoprotein * Moderate levels of physical activity or below (self-identified; NDNS servey) * Omnivores * Not currently using cholesterol lowering medication
Exclusion criteria
* \<18 or \>70 years old * BMI \<27.5 kg/m2 * Allergies to penicillin/mycoprotein * Heavy exercisers (self idenfiied) * Vegetarian/vegans * Currently using cholesterol lowering medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postabsorptive blood cholesterol (free, total, LDL, HDL) concentrations | 4 weeks | Test for intervention vs control differences in postabsorptive blood cholesterol levels (mMol) pre and post intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fingerprick blood glucose concentration | 4 weeks | Test for intervention vs control differences in blood glucose concentration (mMol) in postabsorptive and postprandial state |
| Satiety | 4 weeks | Test for intervention vs control differences in satiety using a 10 centimetre 'Satiety Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of satiety, where 0 cm is minimum and 10 cm is maximum |
| Hedonic visual analogue scale | 4 weeks | Test for intervention vs control differences and changes in hedonic response using 10 cm 'Hedonic Visual Analogue Scale' ratings, anchored by minimum to maximum response for a given aspect of hedonic response, where 0 cm is minimum and 10 cm is maximum |
| Postprandial blood cholesterol concentration | 3 hours | Test for intervention vs control differences in postprandial blood cholesterol levels (mMol) pre and post intervention |
| Fingerprick blood c-peptide | 4 weeks | Test for intervention vs control differences in C-peptide concentration (ng/ml) in postabsorptive and postprandial state |
| Fingerprick blood triglyceride concentration | 4 weeks | Test for intervention vs control differences in blood triglyceride concentration (mMol) in postabsorptive and postprandial state |
| Gastrointestinal side-effects | Once weekly, over 4 weeks | Test for intervention vs control differences in tolerance of diet |
Countries
United Kingdom
Outcome results
None listed