Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04773457

Enrollment

220

Registered

2021-02-26

Start date

2024-02-01

Completion date

2026-12-01

Last updated

2026-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgical Site Infection

Brief summary

Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.

Interventions

OTHERSurgical Site Infection

infection at the site of the surgery (spine or abdomen)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

12 Months to 19 Years

Healthy volunteers

Inclusion criteria

* scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery

Exclusion criteria

* On chronic immunosuppressive drugs such as chronic corticosteroid use * preexisting immunodeficiency diseases

Design outcomes

Primary

Measure	Time frame	Description
Neutrophil populations	up to 3 days	compare neutrophil population between patients with SSI and without SSI by delineating transcriptomic profiles
Neutrophil functional impairment	up to 3 days	illustrate neutrophil subpopulation associated with neutrophil functional impairment and SSIs by probing phagocytosis and reactive oxygen species formation

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORKoichi Yuki, MD

Boston Children's Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 18, 2026