Anesthesia, Local
Conditions
Brief summary
To compare pain during injection, onset of anesthesia and effectiveness of anesthesia using buffered versus non- buffered 2% lidocaine with 1:80,000 adrenaline in dental extraction.
Detailed description
The investigators will conduct a prospective, randomized, single-blinded study, the sample will include 100 patients (extraction) who need dental extraction of upper teeth (premolar and molar teeth). The predictor variable is the use of buffered 2% lidocaine with 1:80,000 adrenaline and non-buffered 2% lidocaine with 1:80,000 adrenaline. The patients will be randomly assigned into two groups of 50 patients each using Microsoft Excel 2016; the first group (study group) will undergo dental extraction after receiving buffered 2% lidocaine with 1:80,000 adrenaline, the second group (control group) will undergo dental extraction after receiving non-buffered 2% lidocaine with 1:80,000 adrenaline. The outcome variables include pain during injection, onset of anesthesia and effectiveness of anesthesia on buffered and non-buffered group.
Interventions
DRUGsodium bicarbonate 8.4%
mixing the sodium bicarbonate with 2%lidocaine and 1:80.000 epinphrine using mixing pen (onset buffering system)
DRUG2%lidocaine with 1:80.000 epinphrine
injection
DEVICEMixing pen (onset buffering system)
Premixing of the two solutions sodium bicarbonate and lidocaine with epinphrine before the local anesthesia adminstration to the patient
Sponsors
University of Baghdad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Give written, informed consent (both the subject and the legal guardian). 2. Be 18-65 years of age. 3.Be able to comprehend the visual analog scale (instructions given to ascertain this). 4.Be able to comprehend the verbal rating scale (instructions given to ascertain this). 5.upper premolars and molars extraction.
Exclusion criteria
1. Patient under 18 years. 2. pregnant women. 3. patient with uncontrolled systemic disease that are contraindicated for dental extraction. 4- patient taking medication that interfere with the assessment of local anesthetic such as narcotics and antidepressants .
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain during Injection | Immediately after Injection | Numerical rating scale from 0-10 that (0) mean no pain and (10) worst pain |
| Onset of anesthesia | 30 seconds to 90 seconds | probing marginal gingiva |
| Effectiveness of anesthesia | during procedure | number of carpules used |
Outcome results
None listed