Acute Kidney Injury, Postoperative Complications
Conditions
Brief summary
Esophagectomy serves as an exemplar of major operative trauma, with well-known risk of pulmonary, cardiac, anastomotic, and septic complications and the presence of postoperative complications after esophagectomies for cancer is associated with a reduced long-term survival. There is a paucity in the literature regarding postoperative renal outcomes after esophageal surgery, with a wide range of incidence. The investigators will conduct a historical cohort study aiming to evaluate the incidence of postoperative acute kidney injury in patients undergoing elective esophageal cancer surgery. Secondary, the investigators will assess the progression of the acute injury and the association with adverse pulmonary, cardiac, anastomotic, and septic events, as well as increase in hospital stay and mortality. The investigators will also identify risk factors associated with acute kidney injury occurrence.
Interventions
None listed
Sponsors
Azienda Ospedaliera di Padova
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Elective esophagectomy
Exclusion criteria
* End-stage renal disease * Missing data for acute kidney injury definition * Second surgery (for patients having multiple surgeries performed during a 30-day period, only the first in each period will be included)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative acute kidney injury | within 48 hours after surgery | according to KDIGO criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with renal recovery | at 7 days, after 30 days and 3 months | according ADQI criteria |
| Incidence of postoperative pulmonary complications | within 30 days after surgery | based on European Perioperative Clinical Outcome (EPCO) definitions |
| Incidence of major adverse cardiac and cerebrovascular events (MACCE) | within 30 days after surgery | composite outcome of non-fatal cardiac arrest, acute myocardial infarction, congestive heart failure, new cardiac arrhythmia, angina, ischemic stroke |
| Incidence of transient or persistent postoperative acute kidney injury | 48 hours after development of acute kidney injury | according KDIGO criteria |
| Mortality in hospital | 1 year | any death during the admission when the operation was performed |
| Increase in length of hospital stay | 1 year | compared to the expected length of hospital stay according ACS NSQIP calculation |
| Incidence of sepsis | within 30 days after surgery | according Sepsis-3 definition |
Countries
Italy
Outcome results
None listed