Immune System
Conditions
Keywords
fraction of inspired oxygen, hyperoxia, immune system
Brief summary
During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.
Detailed description
During anesthesia and surgery, oxygen is routinely administered to all patients. Inspired oxygen concentrations, however, vary between 30% - 100% and oxygen is often administered in a seemingly random manner.A striking conundrum is evident immediately when one review studies on the effects of oxygen on cytokines synthesis. Most investigators have found that hyperoxia enhances proinflammtory cytokines transcription and translations (11). In contrast, hyperparic oxygen has generally been shown to suppress stimulus induced porinflammtory cytokine production (12). Other studies have demonstrated that supplemental oxygen improves inflammatory and immune function (13), and it is not associated with clinically important side effect (14). We therefor undertook the current prospective randomized study to investigate whether perioperative supplemental oxygen (30% versus 80%) on pro and anti-inflammatory response in patients undergoing major abdominal cancer surgeries as our primary outcome.
Interventions
after induction of general anaesthesia, different fraction of inspired oxygen will be given to patient according to their group allocation
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* candidates for abdominal cancer surgeries
Exclusion criteria
* Patients with chronic diseases, such as chronic obstructive pulmonary disease or pneumonia, * body mass index (BMI) \>35 kg/m2, * severe malnutrition (albumin \<3), * leukopenia (white blood cell \<4,000 g/dL), * surgery within the previous 30 days and * O2 saturation \< 90%, as measured using a pulse oximeter
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in serum level of interlukin 6 | before operation (0), 1st, 3rd, and 7th days postoperative | serum level of interlukin 6 will be measured by ELISA technique |
| changes in serum level of interlukin 10 | before operation (0), 1st, 3rd, and 7th days postoperative | serum level of interlukin 6 will be measured by ELISA technique |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in total WBCs count | before operation (0), 1st, 3rd, and 7th days postoperative | measurement of total white blood cells count |
Countries
Egypt
Contacts
Primary ContactShereen M Kamal, Associate Professor
Outcome results
None listed