Measurement of Noradrenaline Concentrations Using Different Dilution Methods

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04772599

Enrollment

Registered

2021-02-26

Start date

2021-02-21

Completion date

2021-07-01

Last updated

2021-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Hypertension

Keywords

Noradrenaline, Norepinephrine, Concentration of noradrenaline, Vasopressor, Baby-noradrenaline, Dilution of Noradrenaline

Brief summary

Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial preparation is increasingly common in the operating room (baby-noradrenaline). In addition, dilution errors are potentially serious for the patient (hypertensive peak) The preparation of precise dilutions is an important factor for the safe use of this medically In this study, the investigators wish to compare the dilution method of the protocol with another method of preparation (left to the free choice of the participant).

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Adult person, * Employee of Strasbourg University Hospitals, * Likely to have to prepare anesthesia drugs in the operating room (intern, hospital student, IADE, IADE student)

Exclusion criteria

\- Subject's refusal to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Measurement of noradrenaline concentrations using different dilution methods	1 hour after the preparation of the noradrenaline solutions	Measurement methods: * High performance liquid chromatography * Measurement of the concentration of noradrenaline in the biochemical laboratory of the University Hospitals of Strasbourg

Countries

France

Contacts

Primary ContactThiên-Nga CHAMARAUX-TRAN, MD

ThienNga.CHAMARAUX-TRAN@chru-strasbourg.fr33 3 88 12 70 75

Backup ContactSaïd CHAYER, PhD, HDR

said.chayer@chru-strasbourg.fr33 3 88 11 66 90

Outcome results