Sarcopenia and Mechanical Ventilation in Older Patients Admitted Due to COVID-19

Sarcopenia and Mechanical Ventilation in Older Patient Admitted With COVID-19 Infection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04772586

Acronym

SARCO-V

Enrollment

Registered

2021-02-26

Start date

2020-09-01

Completion date

2021-08-20

Last updated

2022-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sarcopenia

Keywords

Sarcopenia, Mechanical ventilation, Older patients, COVID-19

Brief summary

The SarcoV study aims at assessing the association between sarcopenia and the indication of mechanical ventilation in older hospitalized patients due to COVID-19 infection

Detailed description

Sarcopenia is disease associated with poor clinical outcomes. In critical ill chirurgical patients, sarcopenia is associated with difficult to wean of mechanical ventilation. The association between sarcopenia and mechanical ventilation is poorly studied in medical patients. COVID-19 pandemic has led a lot of medical patient to be admitted in intensive care units due to acute respiratory failure with need of mechanical ventilation support. The primary objective is to determine if sarcopenia in critically-ill older patients with COVID-19 is associated with the indication of mechanical ventilation. Secondarily, the study aims at determining if sarcopenia is associated with difficult to wean and mortality in critically-ill older patients with COVID-19.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Consecutive patients aged 60 and older * Admission in an acute care unit in Brugmann university hospital due to a COVID-19 possible or confirmed infection. A infection was considered confirmed in presence of a positive molecular test by Polymerase-chain reaction (PCR), following the Belgian Public Health Department recommendations (Sciensano recommendations).

Exclusion criteria

* Patients unable to perform a grip-strength measurement due to any rheumatological or neurological condition.

Design outcomes

Primary

Measure	Time frame	Description
Indication of mechanical ventilation	Through study completion, an average of 60 days	Association between probable sarcopenia and the indication of mechanical ventilation in patients with COVID-19 infection. Mechanical ventilation was considered by non-invasive ventilation or invasive ventilation. For purpose of analysis, it was defined as a binary outcome (yes(no). Probable sarcopenia probable was defined according to the revised European consensus on definition and diagnosis of sarcopenia (EWGSOP2). For purpose of analysis, it was defined as a binary condition (yes/no).

Secondary

Measure	Time frame	Description
Evaluate difficult-to-wean in mechanical ventilation	Through study completion, an average of 60 days	Difficult to wean in mechanical ventilation is defined if the patient required more than 7 days of mechanical ventilation from the first spontaneous breath test or if the patient was reintubated within 48 hours after extubation. For purpose of analysis, it was considered as a binary outcome (yes/no)
All-cause mortality	Through study completion, an average of 60 days	Vital status during hospital admission, at 30- and 60-day follow-up

Countries

Belgium

Outcome results