Alzheimer Disease, Mild Cognitive Impairment
Conditions
Keywords
TMS, Transcranial Magnetic Stimulation
Brief summary
The investigators reviewed 12 years of clinical use in an outpatient neurology setting of transcranial magnetic stimulation (TMS) in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) to evaluate safety and efficacy of TMS.
Detailed description
The investigators compiled demographic, clinical, and neurocognitive data on all patients who had received TMS for any reason in the clinic over a 12-year period. Of 236 patients receiving TMS, 59 patients with AD and 14 with MCI satisfied study criteria and were compared to controls from the National Alzheimer's Coordinating Center (NACC). Neurocognitive outcomes were compared between magnetic resonance imaging (MRI) and electroencephalogram (EEG)-grid guided TMS in patients. Tolerability data was reviewed for all patients.
Interventions
DEVICETranscranial Magnetic Stimulation
Magnetic stimulation to alter neural activity
Sponsors
The New York Memory Services
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for possible or probable Alzheimer's disease. * Patients meeting the National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association (NINCDS- ADRDA) criteria for mild cognitive impairment. * Patients must have undergone at least two standardized neurocognitive batteries before and after beginning TMS. * Patients must have received greater than or equal to five (5) TMS sessions in less than one year.
Exclusion criteria
• Patients with dementias from other causes, such as Lewy Body disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Controlled Oral Word Association Test | 05/01/2008-05/30/2020 | Animal score and percentile |
| Boston 30-item naming test | 05/01/2008-05/30/2020 | spontaneous correct (without cues) |
| Wechsler Adult Intelligence Scale III | 05/01/2008-05/30/2020 | Digit span |
| Wechsler Memory Scale III | 05/01/2008-05/30/2020 | Immediate memory score and percentile |
| Buschke Selective Reminding Test, 12 item | 05/01/2008-05/30/2020 | Total recall score |
| Buschke Selective Reminding Test, 12 item, 15 minute | 05/01/2008-05/30/2020 | Delayed recall score |
| Rosen Drawing Test | 05/01/2008-05/30/2020 | Total score |
| Processing speed | 05/01/2008-05/30/2020 | Total score and percentile |
| Mini-mental status examination | 05/01/2008-05/30/2020 | Total score |
Outcome results
None listed