Cognitive Impairment, Covid19
Conditions
Brief summary
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.
Detailed description
Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.
Interventions
None listed
Sponsors
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Covid-19 patients: * Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago * Asymptomatic at the moment * Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection Healthy subjects: * Not having any of Covid-19 symptoms at the testing time point * Not having any general medical, neurological or psychiatric condition
Exclusion criteria
Covid-19 patients: * Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago * Having any symptom of acute phase of Covid-19 * Having any other general medical, neurlogical or psychiatric contidions Healthy subjects: * Having any of Covid-19 symptoms at the testing time point * Having any general medical, neurological or psychiatric condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological test scores | Up to 90 days | Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Severity of the disease | Up to 90 days | Neuropsychological test score changes according to the disease severity of Covid-19 patients |
Countries
Turkey (Türkiye)
Outcome results
None listed