Gastro Esophageal Reflux, Laryngitis, Laryngopharyngeal Reflux, Laryngopharyngitis Chronic
Conditions
Keywords
Laryngopharyngeal Reflux, Laryngopharyngitis Chronic, Gastro Esophageal Reflux, Laryngitis, pH monitoring, pH metric, acoustic voice analysis
Brief summary
The investigator will issue a Patient Information Consent for the participant in the study. 1.Patients will be asked to complete the Reflux Symptom Index questionnaire. Clinical survey, medical history. 2. Objective methods for assessing the patient's condition: \- examination of ENT organs. 3. Laboratory and instrumental research methods: Endoscopic laryngoscopy and video laryngoscopy, pH-metry, acoustic voice analysis. 4.Sociological method. 5. Subjective methods for assessing the condition of the larynx. 6. Аnalysis of the received data
Detailed description
The investigator will issue a Patient Information Consent for the participant in the study. 1.Patients will be asked to complete the Reflux Symptom Index questionnaire. Clinical survey, medical history 2. Objective methods for assessing the patient's condition: \- examination of ENT organs: rhinoscopy, otoscopy, pharyngoscopy and laryngoscopy 3. Laboratory and instrumental research methods - Endoscopic laryngoscopy and video laryngoscopy. pH-metry: The collection of mucus from the laryngopharynx for the determination of acid-base values. Acoustic voice analysis: objective assessment of the voice condition 4.Sociological method: determination of lifestyle, nutrition, the presence or absence of bad habits. 5\. Subjective methods for assessing the condition of the larynx - Questionnaires. 6\. Аnalysis of the received data
Interventions
DIAGNOSTIC_TESTpH metry
The collection of mucus from the laryngopharynx to determine the acid-base values through pH-metry.
DIAGNOSTIC_TESTFilling out the questionnaire
Completion of the questionnaire index of reflux symptoms. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. Evaluation results range from 0 to 5, where 0 is an indicator of no problem, and 5 is an indicator of a serious problem
DEVICEEndoscopic laryngoscopy
Video laryngoscopy and assessment of the presence / severity of the symptoms. Evaluation results range from 0 to 4, where 0 is an indicator of no problem, and 4 is an indicator of a serious problem
DEVICEAcoustic voice analysis
acoustic analysis of the voice was performed in singers with voice disorders before and after treatment using program of the Lingwaves
Sponsors
Kazakh Medical University of Continuing Education
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient's informed consent * Age: 18-75 years old * No serious somatic diseases. * Patients with complaints of sore throat, coughing, burning sensation in the throat, coughing, frequent sore throat, difficulty swallowing, lump in the throat, foreign body feeling in the throat, voice changes, heartburn and belching. * Diagnosis: Chronic pharyngitis * Chronic laryngitis
Exclusion criteria
* Disagreement to participate in scientific research * Age: under 18 and over 76 * Severe somatic diseases, organic lesions of the gastrointestinal tract and ENT organs * Patients with pulmonary pathologies * Patients with allergic manifestations (seasonal hay fever, asthma, etc.) * With diagnoses: Acute respiratory diseases * Patients with general neuralgic disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acoustic voice analysis of the main group, Week 0 | at the inclusion to the study | Acoustic analysis of the voice was performed in patients with a voice profession who had a voice disorder using computer program of the Lingwaves. |
| Acidity level of the main group, Week 0 | at the inclusion to the study | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where below 6.5 indicates the acidity of the environment, above 7.5 - alkalinity. |
| Acidity level of the control group 1, Week 0 | at the inclusion to the study | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where below 6.5 indicates the acidity of the environment, above 7.5 - alkalinity. |
| Acidity level of the control group 2, Week 0 | at the inclusion to the study | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where below 6.5 indicates the acidity of the environment, above 7.5 - alkalinity. |
| Index of reflux symptoms of the main group, Week 0 | at the inclusion to the study | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Index of reflux symptoms of the control group 1, Week 0 | at the inclusion to the study | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Index of reflux symptoms of the control group 2, Week 0 | at the inclusion to the study | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Endoscopic laryngoscopy of the main group, Week 0 | at the inclusion to the study | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
| Endoscopic laryngoscopy of the control group 1, Week 0 | at the inclusion to the study | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
| Endoscopic laryngoscopy of the control group 2, Week 0 | at the inclusion to the study | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Acidity level of the main group, Week 4 | at 4 weeks after initial treatment | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where above 7.5 indicates the alkalinity of the medium, below 6.5 - acidic. |
| Acidity level of the control group 1, Week 4 | at 4 weeks after initial treatment | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where above 7.5 indicates the alkalinity of the medium, below 6.5 - acidic. |
| Acidity level of the control group 2, Week 4 | at 4 weeks after initial treatment | The acidity level of the larynx is assessed using litmus paper. The range of acidity levels is from 4.5 to 9.0, where above 7.5 indicates the alkalinity of the medium, below 6.5 - acidic. |
| Index of reflux symptoms of the main group, Week 4 | at 4 weeks after initial treatment | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Index of reflux symptoms of the control group 1, Week 4 | at 4 weeks after initial treatment | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Index of reflux symptoms of the control group 2, Week 4 | at 4 weeks after initial treatment | Patients will be asked to complete the Reflux Symptom Index questionnaire. An analysis of the results of the effectiveness of this method in patients with complaints of sore throat, coughing, burning sensation in the throat, cough, frequent sore throat, difficulty swallowing, lump in the throat, feeling of a foreign body in the throat, voice change, heartburn, belching will be carried out. The severity of the problem is calculated as the summation of all points. The problem is absent if the summation of points is 0. The problem is serious if the summation of points is 5. |
| Endoscopic laryngoscopy of the main group, Week 4 | at 4 weeks after initial treatment | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
| Endoscopic laryngoscopy of the control group 1, Week 4 | at 4 weeks after initial treatment | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
| Endoscopic laryngoscopy of the control group 2, Week 4 | at 4 weeks after initial treatment | Assessment of the state of the larynx on the scale of reflux symptoms. Where the presence and severity of the sign is assessed in points from 0 to 4. Where 0 is an indicator of no problem, and 4 is an indicator of a serious problem. |
| Acoustic voice analysis of the main group, Week 4 | at 4 weeks after initial treatment | Acoustic analysis of the voice was performed in patients with a voice profession who had a voice disorder using computer program of the Lingwaves |
Countries
Kazakhstan
Outcome results
None listed