Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery

Pre-emptive Analgesics for Additional Pain Relief in Impacted Third Molar Surgery by depositing4% Articaine With 1:200000 Epinephrine Using Vazirani-Akinosi Closed Mouth Technique- A Randomized Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04769557

Enrollment

Registered

2021-02-24

Start date

2017-03-04

Completion date

2019-02-27

Last updated

2021-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Impacted Third Molar Tooth

Brief summary

The purpose of the study is to evaluate the efficacy of pre-emptive paracetamol in reducing intra operative pressure and post operative pain after surgical removal of impacted mandibular third molar using visual analogue scale

Interventions

DRUGparacetamol

tablet paracetamol 500 mg

DRUGPlacebo

placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Patients aged 21 years and above * Healthy patients (ASA I) * Patients who are not allergic to the drugs and local anesthetic agents used

Exclusion criteria

* Patients who are on concurrent treatment with NSAIDs or corticosteroids * Patients with pericoronitis or periapical infection

Design outcomes

Primary

Measure	Time frame	Description
intraoperative pain	during luxation of tooth	A 10 mm Visual Analogue Scale with higher score depicting severe pain
postoperative pain	1 day	A 10 mm Visual analogue scale with higher score depicting severe pain

Secondary

Measure	Time frame	Description
Time to rescue medication	upto 360 minutes	minutes
number of patients taking rescue medications	Upto 360 minutes	Total number of patients taking rescue medications

Countries

Malaysia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026