Anesthesia
Conditions
Keywords
mgso4, oxygenation, lung mechanics
Brief summary
The purpose of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery
Detailed description
Background and objectives: morbidly obese patients are characterized by a high prevalence of restrictive lung disease. Respiratory mechanics are significantly altered in obesity. These changes are exacerbated with general anesthesia .Obesity also results in reduced lung and chest wall compliance ,increased lung resistance ,reduced oxygenation.MgSo4 is promising in managing several respiratory disorders.it cause smooth muscle relaxation and reduce airflow obstruction. The objective of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery. the following will be recorded :intraoperative oxygenation,lung mechanics,MAP,HR,EtCO2,plateau and peak airway pressure,sedation score,serum mgso4 level,change in P/F ratio and dynamic lung compliance,respiratory rate postoperative
Interventions
DRUGmg sulphate
mgso4 infusion will start 15 minutes after intubation , 30 mg/kg LBW of 10%mgso4 in 100 ml normal saline I.V ,over 30 minutes followed by 10 mg/kg LBW for 90 minutes
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients age between 21-60 years. * BMI more than 40kg/m2 * Patients with restrictive lung disease(FVC\>70%) * American society of Anesthesiologists(ASA) physical status II * No previous abdominal surgery * Scheduled for laparoscopic bariatric surgery not exceeding 3 hours.
Exclusion criteria
* Patient refusal to participate in the study * ASA physical status more than II * patients with heart failure * Kidney disease * Patients on antiarrhythmic drugs * Patients taking beta or calcium channel blockers * Allergy to study drugs * Patients with combined restrictive-obstructive lung disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pao2 | 5 minutes after intubation to 90 minutes after starting drug infusion | arterial oxygenation during surgery determined by Pao2 |
| Pao2/FIO2 | 5 minutes after intubation to 90 minutes after starting drug infusion | arterial oxygenation during surgery determined by Pao2/FIO2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Static lung compliance | 5 minutes after intubation to 90 minutes after starting drug infusion | will be calculated as:tidal volume/(plateau pressure-positive end expiratory pressure) |
| mg sulphate level | One hour postoperatively | serum mgso4 level |
| dead space | 5 minutes after intubation to 90 minutes after starting drug infusion | dead space will be calculated as : Vd/Vt |
| Dynamic lung compliance | 5 minutes after intubation to 90 minutes after starting drug infusion | will be calculated as :tidal volume/(peak airway pressure-positive end expiratory pressure) |
Countries
Egypt
Outcome results
None listed