MEP and Neuromuscular Blocker

Quantitative Analysis Between Neuromuscular Blocking Agent and Motor Evoked Potential and Analysis of Risk Factors for the Coefficient of Variance of Motor Evoked Potential in Patients Undergoing Brain Tumor Removal Surgery: Population Approach

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04768400

Enrollment

100

Registered

2021-02-24

Start date

2021-03-09

Completion date

2022-05-13

Last updated

2023-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain Tumor

Brief summary

It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.

Interventions

DRUGArm I (MEP)

Arm I (MEP): Motor evoked potential will be measured in various degree of the neuromuscular blockade.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

1\. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential

Exclusion criteria

1. Central or peripheral neuromuscular disease 2. Sensory or motor nerve disorder 3. Allergy to propofol, remifentanil, and rocuronium 4. Patients with pacemaker

Design outcomes

Primary

Measure	Time frame	Description
Amplitude of the motor evoked potential	At intraoperative 0 hr from the start of the anesthetic induction	Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.

Secondary

Measure	Time frame	Description
Amplitude of the motor evoked potential	At intraoperative 0 h from the opening of the dura	Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the opening of the dura.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026