The Bern Perioperative Biobank

The Bern Perioperative Biobank to Define Perioperative Changes of Molecular Markers of Perioperative Organo-dysfunctions, Inflammation, Adverse Events and Disease Progression

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04767685

Acronym

BPBB

Enrollment

547

Registered

2021-02-23

Start date

2011-01-31

Completion date

2021-12-31

Last updated

2022-11-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Surgical Procedure, Operative

Keywords

Genetic association study

Brief summary

The goal of the research is to define clinically relevant molecular markers for increased risk of peri-/ postoperative organo-dysfunctions, inflammation, adverse events and disease progression. To better understand the perioperative impact the investigators aim to determine perioperative levels of molecular markers over time in the available samples and clinical data of the Bern perioperative Biobank (BPBB) cohort to finally increase quality of perioperative care of patients by permitting preventive measures to be taken early in patients at risk.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* 18 years and older * Written informed consent * Non-emergency surgery

Exclusion criteria

* Transient incapacity to consent or insufficient time (\< 6h) to consider study participation * No informed consent * Cognitive impairment/Patients unable to consent * Patients who retrospectively expressed their wish to be excluded

Design outcomes

Primary

Measure	Time frame	Description
Assessing the change of the metabolic profile in the perioperative setting	Before induction of anesthesia as baseline	Surgery causes significant disruption of physiologic metabolism. The investigators currently lack specific markers to assess change of the metabolic profile in the perioperative setting. The investigators aim to identify metabolic markers and their change in the perioperative period in association with patients' clinical outcome.

Countries

Switzerland

Outcome results