Acute Leukemia
Conditions
Keywords
Quantitative MRI, acute lymphoblastic leukemia, bone marrow, children
Brief summary
The study is aimed at assessing changes in the bone marrow of patients from 6 to 18 years old with a diagnosis of acute lymphoblastic leukemia during chemotherapy. Patients of the same age without hematological diseases will be recruited as a control group.
Detailed description
The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the ratio of fat to cells in the bone marrow in children with hematological malignancies, which can help in making a diagnosis and monitoring the response to therapy.
Interventions
DIAGNOSTIC_TESTMRI
Dynamics of Bone marrow fat fraction by mDixon-quant (%)
Sponsors
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. patients from 6 to 18 years old 2. diagnosis of acute lymphoblastic leukemia during chemotherapy 3. patients of the same age without hematological diseases
Exclusion criteria
1. patients less then 6, and older then 18 years old 2. patients who cannot perform the study MRI without general anesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dynamics of Bone marrow fat fraction | Point 1. Before the start of therapy - the starting point. | Dynamics of Bone marrow fat fraction by mDixon-quant (%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| T1 maping (ms) | Point 1. Before the start of therapy - the starting point. Point 2. 15 ± 3 days after the start of the therapy. Point 3. 36 ± 3 days after the start of the therapy. Point 4. through study completion, an average of 2 year | T1 mapping is a magnetic resonance imaging technique used to calculate the T1 time |
| apparent diffusion coefficient (mm2/s) | Point 1. Before the start of therapy - the starting point. Point 2. 15 ± 3 days after the start of the therapy. Point 3. 36 ± 3 days after the start of the therapy. Point 4. through study completion, an average of 2 year | Apparent diffusion coefficient (ADC) is a measure of the magnitude of diffusion (of water molecules) within tissue, and is commonly clinically calculated using MRI with diffusion-weighted imaging (DWI). |
| bone marrow fat fraction (FF) by spectroscopy (%) | Point 1. Before the start of therapy - the starting point. Point 2. 15 ± 3 days after the start of the therapy. Point 3. 36 ± 3 days after the start of the therapy. Point 4. through study completion, an average of 2 year | Fat fraction (FF)-this is the ratio of unconfounded fat signal to the sum of the unconfounded fat and water signals |
| The macromolecular proton fraction (MPF) | Point 1. Before the start of therapy - the starting point. Point 2. 15 ± 3 days after the start of the therapy. Point 3. 36 ± 3 days after the start of the therapy. Point 4. through study completion, an average of 2 year | The macromolecular proton fraction (MPF) is a quantitative MRI parameter determining the magnetization transfer (MT) effect in tissues, and is defined as the relative amount of immobile macromolecular protons involved in magnetization exchange with mobile water protons. |
Countries
Russia
Contacts
Primary ContactNataliia Kriventsova
Backup ContactGalina f Tereshchenko
Outcome results
None listed