Activity, Motor, Diet Habit, Microbial Colonization
Conditions
Keywords
Microbiome, Endocannabinoids
Brief summary
Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.
Detailed description
Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.
Interventions
OTHER3 maximal aerobic tests
Maximal aerobic tests will be performed before diet intervention, after the first diet and after the second diet
Sponsors
Laval University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* women * 20-30 years old * healthy * jogging \>1h/week and \>3h/week of physical activity * bmi 18.5-25
Exclusion criteria
* postmenopausal, pregnancy or lactation * pathology or medication * smoking * more than 7 alcohol consumption/week * food allergy, food intolerance or food aversion * important weight change in the last 6 months * antibiotics in the last 3 months * night worker * pathologies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endocannabinoid level post physical activity | 6 months |
Countries
Canada
Outcome results
None listed