The Effect of Dexmedetomidine on Kidney Function in EVAR

The Effect of Dexmedetomidine on the Incidence of Acute Kidney Injury in EVAR

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04766047

Acronym

DEVAR

Enrollment

200

Registered

2021-02-23

Start date

2021-08-30

Completion date

2024-02-01

Last updated

2021-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, Dexmedetomidine, Endovascular Aortic Repair

Keywords

Acute kidney injury, Dexmedetomidine, EVAR

Brief summary

This study will investigate the effect of dexmedetomidine on the incidence of postoperative acute kidney injury in patients undergoing EVAR under general anesthesia

Detailed description

This study will compare the incidence of AKI after elective EVAR conducted under general anesthesia with and without administration of dexmedetomidine. The AKI will be evaluated through measuring NGAL and c-cystatin.

Interventions

DRUGDexmedetomidine

Administration of dexmedetomidine intraoperatively

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* elective EVAR under general anesthesia * adult patients 18- 85 years old * American society of anesthesiologists (ASA) physical status I - IV

Exclusion criteria

* refusal to participate or sign the informed consent form * GFR \< 50ml/mim * Bradyarrhythmia \<50/min * Hemodynamic instability * Known allergy to Dexmedetomidine * Severe hepatic insufficiency

Design outcomes

Primary

Measure	Time frame	Description
Incidence of Acute Kidney Injury	1st Postoperative Day	Assess the incidence of Acute Kidney Injury after the administration of dexmedetomine

Secondary

Measure	Time frame	Description
Incidence of postoperative ICU admission	Operation day to 5th postoperative day	Record the incidence of unanticipated postoperative ICU admission
Incidence of arrhythmia	Up to 24 hours after surgery	Record the incidence of arrhythmia postoperatively
Incidence of Postoperative Delirium	Operation day to 4th postoperative day	Record the incidence of Postoperative Delirium postoperatively

Countries

Greece

Contacts

Primary ContactEleni Arnaoutoglou, MD, PhD

earnaout@gmail.com+306974301352

Backup ContactKonstantinos Stamoulis, MD, PhD

kosta171970@icloud.com+306973335073

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026