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Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04763161
Acronym
NEUTROSURGERY
Enrollment
90
Registered
2021-02-21
Start date
2026-08-15
Completion date
2027-03-15
Last updated
2026-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Cerebrovascular Accident

Brief summary

The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.

Interventions

PROCEDUREDecompressive hemicraniectomy

Decompressive hemicraniectomy in the context of a malignat sylvian ischaemic cerebral accident

PROCEDUREneurosurgical operation

neurosurgical operation on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.

Sponsors

Fondation Ophtalmologique Adolphe de Rothschild
Lead SponsorNETWORK

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Patients: * Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC. Inclusion Criteria Control: \- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach. Non-inclusion Criteria Patients: * HD carried out in a context of acute cerebral haemorrhage * Pre-existing neurological disability: modified Rankin score \> 2 * Patient benefiting from a legal protection measure Non-inclusion Criteria Controls: * Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage. * Patient operated on for an osteomeningeal pathology present at the approach site. * Patient operated on for an infectious cranial or neuro-meningeal pathology. * Patient to be operated on as a result of an intracranial traumatic condition

Design outcomes

Primary

MeasureTime frame
neutrophil polynuclear cells levelsDay 0

Contacts

CONTACTBenjamin MAIER, Professor, MD, PhD
bmaier@for.paris01 48 03 72 13
CONTACTAmélie Dr YAVCHITZ, MD
ayavchitz@for.paris01 48 03 64 54

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026