Aplastic Anemia, Aplastic Anemia Idiopathic
Conditions
Keywords
Quantitative MRI, trepanobiopsy, Aplastic Anemia Idiopathic, children
Brief summary
The study is aimed to find correlation between the assessment of cellularity according to trepanobiopsy data and the results of measuring MRI parameters.
Detailed description
The ratio of fat to water in the bone marrow depends on the cellularity of the bone marrow. In addition to the water/fat ratio in bone marrow there are also other parameters for quantitative MRI assessment. These include the apparent diffusion coefficient (ACD), the T1 relaxation time, mapping of the macromolecular proton fraction. The undoubted advantage of MRI is its non-invasiveness and the ability to assess any localization of the bone marrow. MRI may become a new non-invasive method for assessing the cellularity of the bone marrow in children with oncohematological diseases.
Interventions
DIAGNOSTIC_TESTBone marrow cellularity by mDixon-quant
if trepanobiopsy was performed during the diagnosis, then comparison with MRI Bone marrow cellularity by mDixon-quant
Sponsors
Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
presence of indications for performing trepanobiopsy: 1. aplastic anemia 2. chronic myeloproliferative disease 3. reactive changes in hematopoiesis
Exclusion criteria
1. Refusal to sign an informed consent to participate in a clinical trial 2. Presence of contraindications for MRI examination 3. Extremely serious condition of the patient at the time of inclusion in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correlation between Bone marrow cellularity by mDixon-quant and trepanobiopsy. | Before the start of treatment | Determination of bone marrow cellularity before starting therapy for the underlying disease. Cellularity according to trepanobiopsy data is the ratio of stromal and hematopoietic cells to fat cells in the bone marrow. Cellularity according to MRI - the ratio of water and fat in the bone marrow using the mDixom Quant. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| T1 maping | Before the start of treatment | T1 mapping (ms) is a magnetic resonance imaging technique used to calculate the T1 time |
| apparent diffusion coefficient | Before the start of treatment | value of apparent diffusion coefficient in mm2/s |
| Percentage of the macromolecular proton fraction (MPF) | Before the start of treatment | Percentage of the macromolecular proton fraction (MPF) |
| Percentage of the bone marrow fat fraction | Before the start of treatment | Percentage of the bone marrow fat fraction (FF) by spectroscopy |
Countries
Russia
Contacts
Primary ContactNataliia Kriventsova
Outcome results
None listed