General Anesthesia With and Without Muscle Relaxation and Muscle Strength Recovery

Comparison of General Anesthesia With Use of Muscle Relaxation and General Anesthesia Without Muscle Relaxation on Recovery of Muscle Strength of the Patients

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04760912

Enrollment

Registered

2021-02-18

Start date

2020-04-01

Completion date

2022-09-20

Last updated

2026-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

General Anaesthesia, Muscle Weakness, Rocuronium

Keywords

Rocuronium, Muscle strength, Residual blockade

Brief summary

Neuromuscular blocking agents are often used during general anesthesia. Also, general anesthesia may be performed without use of neuromuscular blocking agents. Avoiding neuromuscular relaxation enables better muscle strength recovery.

Detailed description

Rocuronium is well used neuromuscular blocking agent during general anesthesia. Although very often used, neuromuscular blocking agents may sometimes have consequence in form of residual neuromuscular block. Tha aim of the study is to compare influence of rocuronium during general anesthesia on muscle strength recovery measured by hand grip dynamometer. Measuremwnt of hand grip strength is perforrmed before and after general anesthesia. This research should contribute to better choice of anesthesia technique and better quality of patient recovery, as studies so far have not been detaily carried out. Hypothesis of the research is that anesthesia without use of neuromuscular blocking agents may enable better recovery of muscle strength in immediate postoperative period.

Interventions

DRUGRocuronium

Rocuronium used for neuromuscular blokade during anesthesia and anesthesia without rocuronium

PROCEDUREGeneral anesthesia for surgery

General anesthesia with standard anesthetic monitoring,

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* patients ASA status I-III for surgery under general anesthesia * signed informed consent for participating in research

Exclusion criteria

* neuromuscular disease * poorly controled chronic or acute cardiovascular, respiratory or autoimmune disease * known allergic reaction to any medication used in this research * pregnancy * refusal to participate in this research

Design outcomes

Primary

Measure	Time frame	Description
Muscle strenght recovery after general anesthesia	Perioperative	Change in muscle strength recovery measured with hand grip dynamometer after general anesthesia with or without rocuronium. Better understanding of mechanism how neuromuscular blockade influences quality if patient recovery due to muscle strength recovery

Countries

Croatia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026