Blood Loss
Conditions
Brief summary
Assessing the efficiency of Prophylactic use of local tranexamic acid during vaginal hysterectomy to reduce blood loss during operation
Detailed description
This randomized control trial will investigate whether local tranexamic acid is efficient for decreasing bleeding during vaginal hysterectomy. The investigators will randomize local placebo (saline) vs. local 1 gr tranexamic acid; local 1gr tranexamic acid diluted in 10 ml saline and local 10 ml saline at the beginning of surgery.
Interventions
DRUGlocal tranexamic acid injection
local tranexamic acid injection to cervix- 1 g tranexamic acid diluted in 10 ml saline
OTHERlocal normal saline injection to cervix
local normal saline injection to the cervix- 20 ml saline
Sponsors
Meir Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* 20-90 years old female patients going through vaginal hysterctomy
Exclusion criteria
* massive bleeding during operation due to major vessles injury * known coagulopathies * sensitivity to tranexamic acid * medical need in tranexamic acid administration during operation due to bleeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood loss during operation - measure in ml | End of surgery | At the end of the surgery, surgeon will measure the blood in the suction can |
Countries
Israel
Contacts
Primary ContactYair Daykan, M.D
Backup ContactGal Cohen, M.D
Outcome results
None listed