Functional Esophageal Disorders, GERD, Irritable Bowel Syndrome, Non-erosive Reflux Disease
Conditions
Brief summary
assess the incidence of the entire spectrum of esophageal disorders and possible theories for overlap in IBS patients using different diagnostic modalities.
Detailed description
In the practice of a gastroenterologist, irritable bowel syndrome (IBS) is the most frequent functional disorder. Its prevalence in the population is 9.8%-12.8%. Its frequency in women is more than men. In some studies, it has been shown that a patient may have an overlap of symptoms of different functional diseases of the gastrointestinal tract. Different researchers have ambiguously assessed the frequency of occurrence of esophageal disorders in patients with IBS. So, based on the publications of different authors, they are found in 15-80% of cases. In a study by N. de Bortoli et al. (2016) noted the association of IBS with functional heartburn in 77% of cases, and with GERD and hypersensitive esophagus (called heartburn associated with reflux) - in 33% of cases. Traditionally, diagnostics of a combination of functional disorders of the esophagus and intestines were based on data X-ray and endoscopic methods. However modern research has shown the importance of using in this group of patients with daily combined pH impedance measurement. Thus, many authors have noted the undoubted advantages of this method in the diagnosis of esophageal disorders. Unfortunately, works devoted to this topic, extremely few in number, and the information obtained in them is quite contradictory, which indicates the need to continue research in this direction.
Interventions
DIAGNOSTIC_TESTUpper endoscopy, esophageal manometry, 24-hour pH monitoring
upper endoscopy determines if there are structural abnormalities in upper Git. esophageal manometry determines if there are motility disorders. 24-hour pH monitoring determines if acid reflux is present or not, and specifies its rate and duration.
Sponsors
Assiut University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Established diagnosis of IBS (according to the Rome criteria of the III revision). * Upper GIT symptoms in the form of heartburn (sometimes belching), a lump in the throat, and non-cardiac chest pain.
Exclusion criteria
* History of thoracic, esophageal, or gastric surgery. * Presence of duodenal or gastric ulcer on upper endoscopy. * Presence of duodenal or gastric cancer on upper endoscopy. * Conditions that prevent the installation of a nasogastric tube (nasopharyngeal formation, severe lumen-facial trauma). * mental disorders state and disability. * Pregnancy and breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of GERD in IBS patients who have upper GIT symptoms | baseline | use the result of the comprehensive examination, upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS. |
| Incidence of Functional esophageal disorders in IBS patient who have upper GIT symptoms. | baseline | use the result of the comprehensive examination, including upper endoscopy, esophageal manometry, and 24h pH monitoring to reveal that comorbid disorders of the esophagus in patients with IBS. |
Contacts
Primary Contactbishoy s shehata, doctor
Backup Contacthossam m Abdelwahaab, Lecturer
Outcome results
None listed