Indexed Aortic Area in Bicuspid Aortic Valve Aortopathy

Relationship Between Indexed Aortic Area and Aortic Diameter in Bicuspid Aortic Valve Aortopathy: A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04756778

Enrollment

Registered

2021-02-16

Start date

2017-01-27

Completion date

2017-08-15

Last updated

2021-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bicuspid Cardiac Valve, Thoracic Aortic Aneurysm

Brief summary

This study aims to determine the relationship between the cross-sectional aortic area/patient height ratio (indexed aortic area) and absolute aortic diameter in proximal thoracic aortic aneurysms associated with a bicuspid valve. This will shed light on whether aneurysms with smaller diameters than those recommended for surgical intervention by guidelines are still at risk of aortic complications attending an abnormally high indexed aortic area.

Interventions

PROCEDUREAortic surgery +/- aortic valve replacement

Replacement of aneurysmal proximal thoracic aorta +/- replacement of diseased bicuspid aortic valve

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>18 years * First-time surgery * Bicuspid aortic valve confirmed * Thoracic aortic aneurysm involving aortic root or ascending aorta

Exclusion criteria

* No available pre-operative cross-sectional imaging * Re-do surgery

Design outcomes

Primary

Measure	Time frame	Description
Median aortic diameter corresponding to aneurysms with IAA >10 cm2/m	Data collection period from 27th January 2017 - 15th May 2017	—
Median aortic diameters in aneurysms	Data collection period from 27th January 2017 - 15th May 2017	As above
Cross-sectional aortic area/patient height ratio in aneurysms	Data collection period from 27th January 2017 - 15th May 2017	Calculation of indexed aortic area in aneurysms
Proportion of aneurysms with cross-sectional aortic area/patient height ratio >10 cm2/m	Data collection period from 27th January 2017 - 15th May 2017	Proportion of aneurysms with an abnormal indexed aortic area
Median cross-sectional aortic area/patient height ratio for aneurysms with diameter <4.0 cm, 4.0-4.5 cm, 4.5-5.0 cm, 5.0-5.5 cm and >5.5 cm	Data collection period from 27th January 2017 - 15th May 2017	—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026