New Protocol in Unexplained Infertility

A Higher Ovulation and Pregnancy Rates in Patients With Unexplained Infertility After Application of ANTIUI Protocol: A Randomized Multicenter Controlled Study

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04754243

Enrollment

200

Registered

2021-02-15

Start date

2021-03-01

Completion date

2024-12-31

Last updated

2023-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unexplained Infertility

Brief summary

The new protocol ANTIUI provides good results regarding ovulation and pregnancy rates in patients with unexplained infertility

Detailed description

Patients with unexplained infertility has normal investigations regarding hormonal, structural data. Semen is normal but no pregnancy occurs. Before trying ICSI, we could help these patients with ANTIUI

Interventions

DRUGGonadotropin

Giving patients gonadotropins and antagonist cetrotide

DRUGStandard protocol in IUI

Giving patients gonadotropins without antagonist cetrotide

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

2 parallel groups each is receiving different intervention

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Unexplained infertility * Duration less than 5 years * Good ovarian reserve AMH\> 1.1 * Normal patent tubes * No previous trials of IUI with the same protocol

Exclusion criteria

* Age \> 35 years * Duration of infertility\> 5 years * Abnormal semen * Hypoplastic tubes * prior failed ICSI

Design outcomes

Primary

Measure	Time frame	Description
Ovulation	6 months	Disappearance of mature follicle
Pregnancy	6 months	Number of pregnant cases

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026