Refractory Epilepsy
Conditions
Keywords
Deep Brain Stimulation
Brief summary
The purpose of this study is to use functional imaging to study the mechanisms of the anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS).
Detailed description
Researchers are testing how changing the settings on deep brain stimulation device (DBS) can help reduce the number and severity of seizures. Functional imaging will be used to study the mechanisms of ANT DBS to optimize the device settings to improve the degree of seizure reduction.
Interventions
DIAGNOSTIC_TESTFunctional magnetic resonance imaging (fMRI)
Diagnostic imaging measuring the metabolic changes that occur within the brain used for measuring and mapping brain activity
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients who have previously undergone anterior thalamic nucleus deep brain stimulation (DBS) for refractory epilepsy.
Exclusion criteria
\- Contraindication to MRI; prior brain resective surgery or large area of brain tissue loss (e.g., large area infarction).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Document brain activation networks with ANT stimulation | Results would be available immediately following processing of the imaging data after each scan | Use resting state fMRI to map brain network activation with high and low frequency of ANT stimulation. |
Outcome results
None listed