Semitendinosus Graft as Meniscal Transplant

Autologous Semitendinosus Tendon Graft as Meniscal Transplant - a Clinical Pilot Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04753424

Enrollment

Registered

2021-02-15

Start date

2018-01-01

Completion date

2026-01-01

Last updated

2022-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ACL, Graft Failure, Meniscus Tear, Osteo Arthritis Knee, Patient Satisfaction

Keywords

meniscus transplantation

Brief summary

Removal of meniscal tissue is described to result in poor knee function and a significant risk for future development of osteoarthritis. Different implants have been suggested to substitute a removed meniscus. Meniscal allograft transplantation is not widely available due to costs and availability. The semitendinosus tendon is a known graft with biological properties with potential to remodel and revascularize in an intraarticular environment such as anterior cruciate ligament reconstruction. The objective for this study was to investigate whether the semitendinosus tendon graft could function as a meniscal transplant.

Interventions

PROCEDURESurgical technique

Description of novel surgical technique using autologous semitendinosus graft as meniscus transplant.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Previous subtotal or total meniscectomy * Post meniscectomy symptoms * No osteoarthritic changes on radiography more than Ahlbäck 1 * Knee aligment (hip-knee-angle) +/- 3° * No persisting ACL insufficiency

Exclusion criteria

* Difficulty understanding the instructions * Current psychiatric diagnosis * Smoking

Design outcomes

Primary

Measure	Time frame	Description
Failure	2 years	Surgical failure of transplant defined as meniscus symptoms (joint line tenderness, swelling, locking or positive McMurray) resulting in a need for re-arthroscopy and subtotal or total resection of the transplant.

Secondary

Measure	Time frame	Description
Improved subjective knee function	2 years	Patient reported outcome measure using the Knee Injury and Osteoarthritis Outcome Score (KOOS), 0-100 where 100 indicate best possible result.

Countries

Sweden

Contacts

Primary ContactKarl Eriksson, Prof

karl.eriksson@ki.se0046707202646

Backup ContactErik Rönnblad, MD

erik.ronnblad@ki.se0046736785549

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026