Bronchodilation, Dopamine, Functional Disturbance, Heart, Surgery
Conditions
Brief summary
Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to the beneficial cardiac effect of this drug, the few previous studies addressing its ability to alter the airway tone reported controversial results. Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary bypass. Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured in the patients before the CPB, immediately after CPB, and 5 min after administration of dopamine (3 mcg/kg/min). The importance of the research is to reveal whether the beneficial mechanical changes after dopamine administrations are associated with improvements in gas exchange outcomes. Clarification of this research question have scientific relevance and may also improves patient outcomes.
Interventions
Administration of dopamine (3 mcg/kg/min) as part of cardiac support therapy after the cardiopulmonary bypass. Administration of dopamine is a subject of clinical decision based on the cardiovascular status of the patients.
Sponsors
Szeged University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Cardial surgery patients undergoing cardiopulmonary bypass procedures
Exclusion criteria
* Chronic respiratory diseases, elderly (\>80 years)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial oxygen partial pressure (PaO2) | 5 min after administration of dopamine | Partial pressure of oxygen in the blood sample assessed by a blood gas analyser. |
| Arterial carbon dioxide partial pressure (PaCO2) | 5 min after administration of dopamine | Partial pressure of carbon dioxide in the blood sample assessed by a blood gas analyser. |
| Lung mechanics | 5 min after administration of dopamine | Airway resistance, lung tissue damping and lung tissue elastance obtained by forced oscillation technique. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Capnography | 5 min after administration of dopamine | Time capnography to obtain phase 3 and phase 2 slopes. |
| Intrapulmonary shunt | 5 min after administration of dopamine | Intrapulmonary shunt obtained by the Berggren shunt equation from arterial and central venous blood samples. |
Countries
Hungary
Outcome results
None listed