Hypocalcemia, Thyroid Diseases, Vocal Cord Dysfunction
Conditions
Keywords
Thyroidectomy, Postoperative Hypocalcaemia, Postoperative Vocal cord dysfunction, Dexamethasone
Brief summary
Total thyroidectomy for benign surgical pathologies is associated with risks related to temporary hypocalcaemia and vocal quality dysfunction. Dexamethasone, as an anti-inflammatory steroid, has been proposed to have a physiological effect on hypocalcaemia and voice quality. Investigators conducted a double-blinded controlled trial to assess the effect of preoperative dexamethasone on the vocal dysfunction and hypocalcaemia following thyroidectomy
Interventions
DRUGDexamethasone
8 mg/2 ml dexamethasone IV, 60 minutes before the induction of anaesthesia
DRUGPlacebo
2 ml normal saline (0.9%) IV, 60 minutes before the induction of anaesthesia
Sponsors
Holy Family Hospital, Pakistan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Benign thyroid condition. * Patients without any preoperative corrected hypocalcaemia and voice or vocal quality dysfunction.
Exclusion criteria
* Previous thyroid or neck surgery * Known vocal cord dysfunction on laryngoscopy * Hearing or voice problems * History of gastroesophageal reflux and stomach ulcer disease * Contraindications of steroids
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypocalcaemia | 3 days | Hypocalcaemia was defined as a corrected serum calcium level of less than 2 mmol/L. |
| Voice dysfunction | 24 hours | Signs and symptoms of voice dysfunction at 24 hours after thyroidectomy. Voice dysfunction was defined on voice analogue score from 0-100. Participants with Voice Analogue Score of less than 50 were labelled as having voice dysfunction, and participants with score more than 50 were considered as normal. |
Outcome results
None listed