Amitriptyline vs GON and SON Blocks in Migraine

Comparison of Amitriptyline and Nerve Blocks (GON and SON) in Patients With Migraine

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04750967

Enrollment

Registered

2021-02-11

Start date

2021-04-03

Completion date

2023-07-15

Last updated

2023-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine, Headache

Keywords

greater occipital nerve, supraorbital nerve, nerve blocks

Brief summary

Comparison of efficacy and safety of amitriptyline and nerve blocks

Detailed description

This study aims to compare the efficacy and safety of amitriptyline and nerve blocks (greater occipital nerve and supraorbital nerve)

Interventions

DRUGLidocaine 1% Injectable Solution

Repeated injections of lidocaine to greater occipital nerve and supraorbital nerve once a week for first four weeks then once a month for five months

DRUGAmitriptyline

Amitriptyline 25 mg daily

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Diagnosed with migraine according to ICHD-3

Exclusion criteria

* Being over 50 years or under 18 years * Malignancy and other systemic diseases

Design outcomes

Primary

Measure	Time frame	Description
Number of Participants with 50% Reduction of Headache Frequency	6 months	Monthly headache frequency will be followed

Secondary

Measure	Time frame	Description
Side effects	6 months	Major and minor side effects will be followed

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026