Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04750863

Acronym

AOSD-DIF

Enrollment

312

Registered

2021-02-11

Start date

2010-07-15

Completion date

2021-02-01

Last updated

2021-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Onset Still Disease

Keywords

adult onset still disease, differential diagnosis, diagnosis performance

Brief summary

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Detailed description

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Other conditions such as cancer, infection or other inflammatory disease might mimick its symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up after an initial diagnosis of AOSD. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Interventions

OTHERdiagnosis criteria performance

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adults * with glycosylated ferritin dosage for suspected adult onset still disease * with at least 18 month of follow-up

Exclusion criteria

* known infectious disease * known cancer * known active connective tissue disease or vasculitis

Design outcomes

Primary

Measure	Time frame	Description
diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up	after 18 months of follow-up	Sensitivity, Specificity, positive predictive value, negative predictive value

Secondary

Measure	Time frame
description of differential diagnosis mimicking adult onset still disease	after 18 months of follow-up
identifying factors associated with the occurence of a differential diagnosis during follow-up	after 18 months of follow-up

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026