SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)

Conditions

SARS-CoV Infection

Brief summary

The study aims to investigate SARS-CoV-2 susceptibility, transmission and disease severity in healthcare workers and patients. Residual specimens from an existing collection of samples in viral inactivating buffer and derivatives and serum from the Crick COVID-19 Consortium Testing centre (Cohort A1) and additional biological material collected prospectively (Cohorts A2 and B) will be used for research into SARS-CoV-2 transmission, evolution and immune control. This testing centre is a partnership between UCLH and The Francis Crick Institute to provide COVID 19 RT PCR testing for healthcare workers (HCWs) and patients in London Hospitals and care homes. A third group (Cohort C) of the study will allow for collaborative work with other REC approved research studies that have used the Crick COVID-19 Consortium Testing centre and will involve the use of study samples already collected from each study to be analysed under the SARS-CoV-2 Longitudinal Study end points

Ahimbisibwe G, Greenwood D, Wilkinson KA, Gahir J, Townsley H, Miah M, Bawumia P, Chaloner C, Levi D, Hobson P, Riddell A, Hobbs A, Dowgier G, Penn R, Sanderson T, Stevenson-Leggett P, Daley O, Bazire J, Harvey R, Fowler AS, Smith C, Miranda M, O'Reilly N, Warchal S, Ambrose K, Strange A, Kelly G, Kjar S, Legacy Investigators, Williams B, Libri V, Gamblin S, Gandhi S, Swanton C, Bauer DL, Wilkinson RJ, Carr EJ, Wall EC.

2025-08-21

10.1016/j.jinf.2025.106598

Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study.

Russell TW, Townsley H, Hellewell J, Gahir J, Shawe-Taylor M, Greenwood D, Hodgson D, Hobbs A, Dowgier G, Penn R, Sanderson T, Stevenson-Leggett P, Bazire J, Harvey R, Fowler AS, Miah M, Smith C, Miranda M, Bawumia P, Mears HV, Adams L, Hatipoglu E, O'Reilly N, Warchal S, Ambrose K, Strange A, Kelly G, Kjar S, Papineni P, Corrah T, Gilson R, Libri V, Kassiotis G, Gamblin S, Lewis NS, Williams B, Swanton C, Gandhi S, Beale R, Wu MY, Bauer DLV, Carr EJ, Wall EC, Kucharski AJ.

2024-09-115 citations

10.1016/s1473-3099(24)00484-5

COVID-19 in non-hospitalised adults caused by either SARS-CoV-2 sub-variants Omicron BA.1, BA.2, BA.4/5 or Delta associates with similar illness duration, symptom severity and viral kinetics, irrespective of vaccination history

Hermaleigh Townsley, Joshua Gahir, Timothy Russell, David Greenwood, Edward J Carr et al. (37 authors)

PLoS ONE2024-03-2111 citations

10.1371/journal.pone.0294897

Combined analyses of within-host SARS-CoV-2 viral kinetics and information on past exposures to the virus in a human cohort identifies intrinsic differences of Omicron and Delta variants

Timothy Russell, Hermaleigh Townsley, Sam Abbott, Joel Hellewell, Edward J Carr et al. (26 authors)

PLoS Biology2024-01-3016 citations

10.1371/journal.pbio.3002463

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Individuals who have previously provided nasal throat swab samples for SARS-CoV-2 testing at the Crick COVID 19 Consortium Testing centre. * ≥18 years of age * To enrol in the SARS-CoV-2 positive cohort of the study, the participant should have a positive RT qPCR result * Employees based at the participating sites including who had their serology and/or swab tested (for recruitment to Cohort B) * Participants enrolled in other studies who had their samples processed by using the Crick COVID 19 Consortium Testing centre (for recruitment to Cohort C). * Written informed consent (except Cohort A1)

Design outcomes

Primary

Measure	Time frame	Description
SARS-CoV-2 susceptibility in healthcare workers and patients	24 months	To investigate SARS-CoV-2 susceptibility by examining the number of positive SARS-CoV-2 result per participant
SARS-CoV-2 transmission in healthcare workers and patients	24 months	To investigate SARS-CoV-2 transmission by analysis of samples sequencing data from each study centre and across study centres
SARS-CoV-2 severity in healthcare workers and patients	24 months	To investigate SARS-CoV-2 severity by review of symptom severity

Countries

United Kingdom

Contacts

Primary ContactCharles Swanton

crick-legacy@crick.ac.uk020 3796 0000

Outcome results