Constitutionally Lean Women, Healthy Normal Weight Women
Conditions
Keywords
energy metabolism, body composition, physical training, constitutional leanness
Brief summary
The main aim of the present study is to compare the effect of a 12-week physical activity program on body weight gain and body composition changes between normal weight and constitutionally lean individuals. The second objective will be to question the potential additional effect of a protein supplementation coupled to the physical training intervention on body wright and body composition in constitutionally lean women.
Detailed description
After a medical inclusion visit, the participants will realize a maximal aerobic test at the university hospital as well as a body composition analysis, a blood sample will be taken, their resting metabolic rate will be assessed as well as their energy metabolism during a rectangular cycling exercise. Their muscle strength and architecture will be assessed. Their energy intake and eating habits will also be assessed as well as their diet-induced thermogenesis in response to a fixed and an ad libitum meal. Their sleep metabolism will also be assessed using the Dreem technology. Questionnaires will be used to evaluate their daily free living energy intake and accelerometers used to assess their daily physical activity level. The participants will then perform a 12-week physical activity intervention with 15 of the 30 constitutionally lean one receiving a protein supplementation (randomly assigned). All the measures will be replicated at the end of the intervention as well as 6 weeks after
Interventions
BEHAVIORALPhysical training alone
The physical activity intervention will consist in 12 weeks of training composed of 3 sessions per week. The three sessions will be mainly composed of resistance training aiming at increasing body weight through increased fat free mass. The main muscle groups (lower limbs, upper limbs and trunk) will be trained. The intervention will be performed under the supervision of a specialized coach.
BEHAVIORALphysical training + protein intake
The physical activity intervention will consist in 12 weeks of training composed of 3 sessions per week. The three sessions will be mainly composed of resistance training aiming at increasing body weight through increased fat free mass. The main muscle groups (lower limbs, upper limbs and trunk) will be trained. The intervention will be performed under the supervision of a specialized coach. 15 women with constitutional leanness will, on top of the physical training, received a daily protein supplementation corresponding to 20 grams of proteins + 10 grams of Maltodextrine
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria common to both groups * Adult women aged 18 to 35, having a stable weight for at least 3 months. * Body mass index (BMI) ≤ 17.5 kg / m2 (for the constitutional thinness group) or 20 kg / m2 ≤ BMI ≤ 25 kg / m2 (for the normal-weighted control group) * Able to give informed consent to participate in research. * Affiliation to a Social Security scheme. Inclusion criteria specific to women with constitutional thinness * BMI ≤ 17.5 kg / m2 * Weight stable for at least 3 months * No eating disorder * No biological markers of undernutrition * Absence of secondary amenorrhea Inclusion criteria specific to normo-weighted subjects * 20 kg / m2 ≤ BMI ≤ 25 kg / m2 * Weight stable for at least 3 months * No eating disorder * No biological markers of undernutrition * Absence of secondary amenorrhea
Exclusion criteria
* Pregnant or breastfeeding woman * Severe progressive disease * Medical or surgical history judged by the investigator to be incompatible with this study * Diabetes or any other pathology limiting the application of one or the other trial strategy * History of cardiovascular and / or neuro-vascular pathology, and / or cardiovascular and / or neuro-vascular risk factors (excluding obesity / overweight) * Surgical intervention in the previous 3 months * Taking medications that may interfere with the results of the study * Regular practice of intense physical activity (more than 3 physical activity sessions per week) * Regular consumption of tobacco or alcohol * Special diet * Abnormal plasma levels of IGF-1, estradiol, free T3, cortisol and leptin (only for the constitutional thinness group) * Persons under guardianship or subjects deprived of their liberty by judicial or administrative decision * Person in a period of exclusion from another study * Refusal of participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in body weight from baseline | day 1, day 90, day 145 | body weight using a classical scale at different time : baseline, after the 12-week intervention and after 6 weeks of follow-up . |
| Change in fat mass composition | day 1, day 90, day 145 | fat mass will be assessed using DXA |
| Change in fat free mass composition | day 1, day 90, day 145 | fat free mass will be assessed using DXA |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in aerobic capacities . | day 1, day 90, day 145 | aerobic capacities assessed using indirect calorimetry during a graded cycling exercise |
| Change in resting metabolic rate | day 1, day 90, day 145 | resting metabolic rate assessed using indirect calorimetry during 30 minute rest in a comfortable inclined chair. The is the energy expended at rest in Kilo-Joules. |
| Change in Insulin | day 1, day 90, day 145 | Insulin will be evaluated in blood sample |
| Change in glycaemia, . | day 1, day 90, day 145 | glycaemia will be evaluated in blood sample |
| Change in triglycerides | day 1, day 90, day 145 | triglycerides will be evaluated in blood sample |
| Change in cholesterol | day 1, day 90, day 145 | cholesterol will be evaluated in blood sample |
| Change in leptin | day 1, day 90, day 145 | leptin will be evaluated in blood sample |
| Change in bone structure | day 1, day 90, day 145 | the bone structure will be assessed thanks to DXA and pQCT |
| Change in adiponectin | day 1, day 90, day 145 | adiponectin will be evaluated in blood sample |
| Change in thyroid hormones | day 1, day 90, day 145 | thyroid hormones will be evaluated in blood sample |
| Change in LipoxMax | day 1, day 90, day 145 | the point of maximal use of lipids during exercise will be assessed during a graded exercise composed of 4 stages of 6 minutes each, using indirect calorimetry. |
| Change in Energy intake | day 1, day 90, day 145 | Energy Intake will be assessed using a Three-day dietary report (self-reported) |
| Change in physical activity level measured with an accelerometer | day 1, day 90, day 145 | The time spent at low-moderate and vigorous physical activity will be assessed using a 7-day accelerometry record |
| Change in sleep metabolism assessed with the dreem technology captors | day 1, day 90, day 145 | sleep metabolism assessed during a complete night, using the Dreem technology captors that consists in a simple band around the head during the night. |
| Change in ghrelin | day 1, day 90, day 145 | ghrelin will be evaluated in blood sample |
| Change in muscle strength | day 1, day 90, day 145 | muscle strength assessed thanks to isometric contraction using Biodex. |
| Change in muscle structure | day 1, day 90, day 145 | muscle structure assessed thanks to muscle echography |
Countries
France
Contacts
Primary ContactLise Laclautre
Outcome results
None listed