Cognitive Impairment, Colorectal Cancer, Fatigue, Iron-deficiency, Iron Deficiency Anemia, Quality of Life
Conditions
Brief summary
The aim is to investigate if iron deficiency at the time of colorectal cancer diagnosis has an influence on fatigue, quality of life, cognition and physical ability.
Detailed description
Around 60% of newly diagnosed colorectal cancer patients suffer from iron deficiency at the time of diagnosis. The study hypothesis is that, besides leading to anemia, iron deficiency might be associated with impaired patient report outcomes in the domains of fatigue, quality of life, cognitive impairment and lower physical ability. No previous studies on colorectal cancer patients and iron deficiency are available. The participants (patients suspected of colorectal cancer after endoscopy) will be tested on these parameters. The participants and the investigators are blinded to the patients iron status. The study takes place before any preoperative iron treatment. Multivariate analysis will be used taking into account, gender, age, hemoglobin, tumor stage.
Interventions
DIAGNOSTIC_TESTiron deficiency
Its not an intervention. Its an observational study. The groups are defined based on their iron status
Sponsors
Esbjerg Hospital - University Hospital of Southern Denmark
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients in whom endoscopy has raised suspicion of colorectal malignancy
Exclusion criteria
* non fluent in Danish language * cerebral impairment (ex severe dementia) so that informed consent can not be obtained
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fatigue | up to one months after inclusion | Fatigue sub-scale of Focussed assessment of cancer treatment - anemia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quality of life | up to one months after inclusion | European Organisation for Research and Treatment of Cancer C30 |
| Cognitive ability | up to one months after inclusion | Montreal cognitive assessment |
| peripheral muscular strengths | up to one months after inclusion | hand-held dynamometer |
| mobility and balance | up to one months after inclusion | timed-up-and-go-test |
| endurance | up to one months after inclusion | 6 minutes walk test |
Other
| Measure | Time frame | Description |
|---|---|---|
| post-operative run | 30-days postoperatively | the ability of the above mentioned test to predict the postoperative run (complications/length of stay) |
Countries
Denmark
Outcome results
None listed