Role of Oxidative Stress in COPD
Conditions
Keywords
COPD , oxidative stress, Superoxide Dismutase
Brief summary
Background:Striking feature of Chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection . Many of the pathogenetic pathways involved in COPD and its development tend to be driven by oxidative stress.
Interventions
OTHERoxidative stess markers
markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) .
Sponsors
Minia University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Inclusion criteria
* 1-Forty subjects of COPD who are non-smokers or stopped smoking for more than 6 months Based on the Global Initiative for Chronic Obstructive Lung Disease guidelines, COPD was diagnosed.9 2- Thirty subjects of non smokers healthy control
Exclusion criteria
* Patients of: 1. Acute exacerbation, at the time of the study, of COPD. 2. Any obvious abnormal lung parenchymal lesions. 3. Lung cancer. 4. Congestive heart failure. 5. current smokers 6. Drugs e.g anti-inflammatory , steroids ,analgesics, insulin , antineoplastic, antipsychotic drugs in the previous 2 weeks before the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxidative stress markers in non smokers COPD compared to healthy control | 1month | markers of oxidative stress , Superoxide Dismutase (SOD) and Malondialdehyde (MDA) by ( ELISA Kit SinoGeneClon Biotech Co.,Ltd Catalog No : SG- 10188) . |
Countries
Egypt
Outcome results
None listed