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Assessment of Skeletal Maturity Using Proximal Femoral Epiphysis in Patients With Scoliosis

Validation of the Assessment of Skeletal Maturity Using Femoral Head in Patients With Idiopathic Scoliosis and Its Clinical Implications

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04746417
Enrollment
70
Registered
2021-02-09
Start date
2021-02-01
Completion date
2026-02-01
Last updated
2026-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Scoliosis

Brief summary

This study aims to explore the use of proximal femoral head for the assessment of skeletal maturity in patients with idiopathic scoliosis. The aim is to validate the use of the stages of proximal femoral epiphyseal closure in assessing pubertal growth landmarks in this patient cohort. The grading system of this skeletal maturity index will be established and its reliability and reproducibility in clinical use will be examined.

Detailed description

There are multiple skeletal maturity measures currently in use which were established with reliability in assessing growth. The advantages and shortcomings of each index was previously examined. This study aims to explore the use of proximal femoral epiphysis, which is in close proximity of the radiographic field of the spine, in assessing the growth status of patients with idiopathic scoliosis. The stages of the proximal femoral epiphyseal ossification has been established with specific definitions. The reliability and reproducibility of using these gradings will be examined by orthopaedic surgeons. Subsequently, the assessment of different pubertal growth landmarks using these gradings will be validated, and to see whether these gradings can provide indications of peak growth and growth cessation. Finally, the relationships of such growth assessment using this proximal femoral epiphysis ossification (PFEO) system and the curve progression in idiopathic scoliosis will be studied.

Interventions

None listed

Sponsors

The University of Hong Kong
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
6 Years to 18 Years

Inclusion criteria

* Idiopathic scoliosis * Open triradiate cartilage or open distal radius epiphysis without capping

Exclusion criteria

* Non-idiopathic scoliosis * Patients with growth hormone deficiency or developmental delay * Patient has not reached skeletal maturity * Defaulted and lost to follow-up

Design outcomes

Primary

MeasureTime frameDescription
PFEO stages8 to 18 yearsGrade 1 to Grade 6

Secondary

MeasureTime frameDescription
Growth parameters8 to 18 yearsStanding body height

Countries

Hong Kong

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 30, 2026