Eye Infections
Conditions
Keywords
Disinfection, Pre-operative, Povidone Iodine, Eye surgery
Brief summary
Topical povidone-iodine (PI) is widely used as ocular antiseptic before and after surgery. The standard dose of 5% PI is however, associated with ocular irritation. We therefore want to test if a lower concentration of PI can be similarly efficacious in reducing bacterial growth while reducing ocular irritation.
Interventions
DRUGPovidone-Iodine 0.3%
Low concentration iodine
DRUGPovidone-Iodine 5%
Standard concentration iodine
Sponsors
St. Olavs Hospital
Norwegian University of Science and Technology
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Intervention model description
Both eyes of the participants are tested; one eye randomised to receive the intervention and the second eye to receive the standard disinfection.
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients remitted to intravitreal injections at St. Olavs hospital. * Patients competent to give written consent
Exclusion criteria
* Infectious disease * Known epitheliopathy * Contact lens wear * Use of prescription ophthalmic medications * Diabetes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Conjunctival bacterial culture | 1 hour. Bacterial sample is taken before and immediately after disinfection | Change in colony-forming units (CFU) per milliliter (ml) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Patient pain score | During disinfection and after 1 hour when the anesthetic no longer is effective | Verbal numeric rating scale, from 0 to 10. |
| Ocular staining score (OSS) | 1 hour after disinfection | Modified OSS using fluorescein dye |
Countries
Norway
Outcome results
None listed