Covid19, Leukemia, Acute, Leukemia, Lymphoblastic
Conditions
Brief summary
The purpose of this study is to describe the main clinical characteristics of patients with de novo acute lymphoblastic leukemia treated inside the third level hospitals converted to Coronavirus disease 2019 (COVID-19) attention for the metropolitan area of Mexico City.
Detailed description
Retrospective, observational study in patients with diagnosis of acute lymphoblastic leukemia, according to the criteria of the World Health Organization, from April 2020 to December 2020. Patients was cared for in the hematology department of the Hospital Regional de Alta Especialidad de Ixtapaluca or the Hospital General de México. Both hospitals have been assigned as Coronavirus disease 2019 (COVID-19) hospitals, limiting the access, number of outpatient visits and chemotherapy protocols. Real-time polymerase chain reaction (RT-PCR) test for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was performed for patients with respiratory symptoms or history of contact with suspected / confirmed cases of COVID-19 Upon having a positive RT-PCR test, patients were transferred to a respiratory isolation unit to continue their recovery. Support treatment for COVID-19 was based on local considerations.
Interventions
None listed
Sponsors
Hospital General de Mexico
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with diagnosis of acute lymphoblastic leukemia according to the criteria of the World Health Organization.
Exclusion criteria
* Age less than 18 years * Incomplete medical records
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall survival | through study completion, an average of 1 year | — |
| Progression free survival | through study completion, an average of 1 year | — |
| Number of relapses | through study completion, an average of 1 year | Cases with more than 5 percent of blasts in bone marrow and as relapse to the central nervous system with the presence of blasts in cerebrospinal fluid |
| Complete Remission | through study completion, an average of 1 year | Bone marrow has less than 5 percent blast cells, blood cell counts are within the normal range, and there are no signs or symptoms of leukemia |
| COVID-19 confirmed | From the date of leukemia diagnosis to the end of the induction chemotherapy cycle 1 (each cycle is 28 days) | Reactive SARS-CoV-2 RT-PCR test |
Countries
Mexico
Outcome results
None listed