Ulcerative Colitis
Conditions
Keywords
ulcerative colitis, cardiovascular risk, CIMT
Brief summary
An increased risk of cardiovascular (CV) diseases has been observed in patients with inflammatory bowel diseases (IBD). The impact of IBD drugs, such as anti-TNF, anti-integrins or anti-JAK, on the risk of CV events in IBD is remains unknown. Aortic pulse wave velocity (aPWV), a measure of aortic stiffness, and carotid intima media thickness (CIMT) are both predictors of cardiovascular events and are increased in patients with IBD. The investigators aimed to prospectively compare the CV risk, CIMT, arterial stiffness and biomarkers of endothelial dysfunction at baseline and after 3 and 12 months of anti-TNF, vedolizumab and tofacitinib.
Interventions
OTHERAortic pulse wave velocity
Aortic pulse wave velocity (aPWV) is a measure of aortic stiffness
OTHERcarotid intima media thickness (CIMT)
carotid intima media thickness (CIMT)
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ulcerative colitis evolving for at least 6 months, * Patient older than 18 years, * Initiating a treatment by infliximab, adalimumab, golimumab, vedolizumab or tofacitinib, * Written informed consent.
Exclusion criteria
* Patients with anti-hypertensive, antiplatelet or lipid-lowering drugs without stable dosage within the 3 months before the study and over the study period, * Patients with a cardiovascular event such as myocardial infarction and stroke, * Diabetic patient, * Pregnant women, * Minor * people unable to give their consent to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| variation of carotid intima media thickness (CIMT) between the 3 patient groups | at the end of month 3 |
Countries
France
Contacts
Primary ContactMathurin Fumery, Pr
Outcome results
None listed