Postoperative Nausea
Conditions
Brief summary
The investigators investigate the association between the administration of glycyrrhizin during induction of general anesthesia and the occurrence of postoperative nausea and vomiting (PONV) in patients undergo breast surgery
Detailed description
Postoperative nausea and vomiting (PONV) is one of a common complication after general anesthesia with 30-50% of incidence, increased up to 80% in high risk group. The risk factors of PONV include women population, the previous history of PONV, motion sickness in usual life, non-smoker, exposure to inhalants, perioperative opioid and laparoscopic surgery. Women population is a strong risk factor of PONV. Although perioperative management of PONV based on a guideline has been done in a lot of medical centers worldwide, the incidence of PONV is still reported relatively high. The main ingredient of Glycyrrhizin is liquorice which has been used as antispasmodics, antiemetics or treatment for gastric ulcer in oriental medicine. Utilizing these effects of liquorice, the investigators investigate whether the addition of glycyrrhzin to conventional antiemetics is effective to decrease the incidence of PONV and improvement of severity of PONV.
Interventions
DRUGAmmonium Glycyrrhizinate
In control group, we assess the incidence and severity of PONV when participants are aministered ramosetron and placebo. In intervention group, the outcomes are assessed as a result of administration of ramosetron and glycyrrhizin.
Sponsors
Konkuk University Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Participants are blinded to allocated groups. Outcomes assessors are blinded to which group participants are assigned.
Intervention model description
The anticipants are administered either ramosetron+placebo or ramosetron+glycyrrhizin
Eligibility
Sex/Gender
FEMALE
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* participants scheduled to undergo breast surgery aged 20 and above
Exclusion criteria
* aldosteronism * electrolyte imbalance * myopathies * drug addiction or suspected * bowel disease * allergy to drugs * smoker * taking any medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of postoperative nausea and vomiting (PONV) | up to 24 hours after discharge from postanesthetic care unit (PACU) | assessing the incidence of postoperative nausea and vomiting with ordinal scale (0=none, 1=nausea, 2=retching, 3= vomiting) |
Countries
South Korea
Outcome results
None listed