Motor Function, tDCS
Conditions
Brief summary
Transcranial direct current stimulation (tDCS) is a noninvasive method of modulating brain activity and has therapeutic potential in many neurological and psychiatric conditions. However, unlike every current FDA-approved form of brain stimulation, there is no method of individualizing stimulation dose. In this study, a method of individualizing tDCS dose on behavioral outcomes and whether this could help to improve the consistency and magnitude of the stimulation effects will be tested.
Interventions
DEVICESham transcranial direct current stimulation
Participants will receive 30 seconds of ramp up and down stimulation at the start and end of the 20 minute stimulation period.
Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at the individualized dose (maximum of 4mA).
DEVICE2mA transcranial direct current stimulation
Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at a 2mA dose.
DEVICE4mA transcranial direct current stimulation
Participants will receive 20 minutes of transcranial direct current stimulation (tDCS) at a 4mA dose.
Sponsors
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Medical University of South Carolina
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy volunteers or chronic stroke participants (at least 6 months prior to the study) * No history of epilepsy * No metal in the body * No contraindications for TMS or MRI scanning * Right handed * Ability to find motor hotspot and acquire motor evoked potentials
Exclusion criteria
* Metal in the body * History of epilepsy or claustrophobia * Alcohol or substance abuse or dependence * Current treatment for any psychiatric conditions (pharmacological or otherwise) * Pregnant or actively breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Motor Evoked Potential Variance | Baseline and post-stimulation (20 minutes apart) | MEP variance is measured by single pulses of transcranial magnetic stimulation and contralateral hand electrodes. |
| Difference in Motor Evoked Potential Amplitudes from 4mA and 2mA Stimulation | Baseline and post-stimulation (20 minutes apart) | MEP amplitude is measured by single pulses of transcranial magnetic stimulation and contralateral hand electrodes. |
Countries
United States
Outcome results
None listed