Research on Translational Outcomes of Alcohol (Project RETRO)

Status

Withdrawn

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04742348

Enrollment

Registered

2021-02-08

Start date

2023-02-28

Completion date

2023-08-31

Last updated

2023-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Drinking

Brief summary

The primary aim of the current study is to assess the effect of a single dose of carbidopa-levodopa on ad libitum alcohol consumption and alcohol craving in young adults with a history of binge drinking.

Detailed description

This is a small (N = 42) 2-arm, double-blind, randomized controlled pilot study to assess the effect of a single dose of immediate release carbidopa-levodopa (50mg/500mg) to acutely reduce alcohol consumption and craving in college students with a history of heavy episodic drinking. Participants will be between 21-24 years old from 2- and 4- year colleges in the Seattle Metropolitan area. Interested students will contact the study line and provide verbal consent to be sent a link to an online screening survey. Eligible participants will be scheduled to come in for the ad libitum alcohol administration. Participants will receive either the carbidopa-levodopa or a placebo and complete the alcohol administration protocol.

Interventions

DRUGCarbidopa Levodopa

Participants who are randomized to active drug group will receive 1 dose of immediate release carbidopa-levodopa (50mg/500mg) .

DRUGPlacebo

Participants who are randomized to placebo group will be provided with similar looking tablet(s) as the active drug.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

21 Years to 24 Years

Healthy volunteers

Yes

Inclusion criteria

* Enrolled in 2- or 4-year college program * Currently living in the Seattle Metropolitan area * Have at least two or more episodes of heavy episodic drinking (4/5 or more drinks in a 2 hours for women/men) in the past 30 days.

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
Alcohol Consumption	1 hour	Number of alcoholic drinks consumed
Alcohol Craving	30 minutes in to alcohol administration	Amount of alcohol craving as assessed by the Alcohol Urge Questionnaire by Bohn, Krahn & Staehler (1995)

Secondary

Measure	Time frame	Description
Alcohol craving	At the end of alcohol administration. Alcohol administration is 1 hour.	Amount of alcohol craving as assessed by the Alcohol Urge Questionnaire by Bohn, Krahn & Staehler (1995)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026