Systematic IPP VS Symptomatic IPP in GERD Prevention After POEM for Achalasia. . A Comparative Retrospective Analysis

Interest of Systematic PPI Therapy After POEM vs Symptomatic Use of PPI Therapy in Prevention of Gastroesophageal Reflux Disease After POEM for Esophageal Achalasia. A Comparative Retrospective Analysis.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04740437

Acronym

IPPOEM-Retro

Enrollment

150

Registered

2021-02-05

Start date

2017-01-01

Completion date

2022-03-31

Last updated

2021-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Achalasia, Gastroesophageal Reflux

Keywords

GERD, POEM, Achalasia, PPI, Esophagitis

Brief summary

POEM is a minimally invasive endoscopic therapy that is highly efficacy in the treatment of achalasia of any type. POEM has an increased risk of GERD. Systematic PPI therapy has never been studied for the prevention of post-POEM GERD. The investigators wish to retrospectively compare patients who have received routine PPI therapy vs. patients who don't.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* \> 18 years old * Consent given * Achalasia all types with eckhardt score \> 3

Exclusion criteria

* Patient who is a minor or under judicial protection * Pregnant or breastfeeding woman * Contraindication to PPIs * Carrier of mediastinal and exogastric neoplasia * Patient on PPIs prior to the procedure for indication that does not allow for their discontinuation * Peptic esophagitis (Grade B, C or D) before or at the time of the procedure * Previous treatment with Heller myotomy

Design outcomes

Primary

Measure	Time frame	Description
Number of Esophagitis	1 day	Number of Esophagitis

Countries

France

Contacts

Primary ContactAntoine Debourdeau, MD

antoinedebourdeau@hotmail.com467330224

Backup ContactMathilde Charrier, MD

mathilde.snv@gmail.com467330224

Outcome results