Neurocognitive Disorders, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio
Conditions
Keywords
Neurocognitive disorders, Neutrophil-Lymphocyte ratio, Platelet-Lymphocyte ratio
Brief summary
Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to investigate whether the values of NLR and PLR in patients undergoing elective non-cardiac surgery under general anesthesia, are related with increased risk of perioperative NCD.
Detailed description
It is estimated that approximately 10% of elderly undergoing surgery will develop cognitive changes perioperatively, while in some reports the incidence rises up to 80%. Despite the reported high prevalence of perioperative neurocognitive disorders (NCD), their exact etiology is still largely unknown. Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to investigate whether the values of NLR and PLR in patients undergoing elective non-cardiac surgery under general anesthesia, are related with increased risk of perioperative NCD.
Sponsors
University Hospital, Ioannina
Larissa University Hospital
University of Thessaly
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 45 - 80 years * American Society of Anesthesiologists physical status I to III * elective general, urological, gynecological and orthopedic surgery under general anesthesia * native speakers of the Greek language
Exclusion criteria
* refused to participate or sign the informed consent form * had undergone surgery or anesthesia within the last 30 days * had any prior or current history involving an affliction of the central nervous system * were diagnosed with severe cognitive decline based on the 16 - item Informant Questionnaire on Cognitive Decline (IQCODE - 16) * suffered from severe hearing or visual impairment * any psychiatric disorder * had a score \>5 in the Geriatric Depression Scale (GDS - 15) * or a score in females \< 4 males \< 2 in the Lawton - Brody Instrumental Activities of Daily Living Scale (I.A.D.L.) * reported alcohol consumption \> 35 units/week * drug dependence * had undergone previous neuropsychological testing * Diabetes Mellitus type II with \> 10 years of diagnosis * Diabetes Mellitus type I * Hemoglobin A1c (HbA1c) \> 7.5% * suffered from hemodynamical instability (\> 20% alterations of blood pressure perioperatively) * or desaturation (one or more events of SpO2 \< 80% for more than 2 minutes) peri-operatively * or blood loss of more than one unit
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Postoperative neurocognitive disorders assessed with CAM | 1st postoperative day | Incidence of POD assessed with CAM |
| Incidence of Postoperative neurocognitive disorders assessed with IQCODE-16 | 10th postoperative day | Incidence of POCD assessed with IQCODE-16 |
Countries
Greece
Contacts
Primary ContactMaria Ntalouka, MD, PhD
Backup ContactMetaxia Bareka, MD, PhD
Outcome results
None listed