Laryngeal Stenosis, Larynx Disease
Conditions
Keywords
laryngeal stenosis, laryngeal MRI, laryngeal CT, pulmonary test, laryngoscopy
Brief summary
To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.
Detailed description
The study include patients with laryngeal pathology in the otorhinolaryngology clinic of the 1-city hospital at Nur-Sultan city. All patients cheek up the necessary clinical, functional, diagnostic studies and treatment measures. It is planned to examine and operate on 70 patients with laryngeal pathology. 1. To study the features of the course of stenosis of the larynx under the influence of various factors, as well as traumatic injuries. 2. To develop optimal diagnostic methods for patients with laryngeal stenosis. 3. To assess the effectiveness of endolaryngeal microsurgery in patients with laryngeal stenosis. 4. To develop recommendations for the organization of treatment for stenosis of the larynx with an increase its functional state.
Interventions
DIAGNOSTIC_TESTspirometry
spirometry
RADIATIONMRI and CT
MRI and CT
OTHERLaryngoscopy
laryngoscopy
OTHERelectromyography
electromyography
Sponsors
Astana Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Parallel Assignment, prospective, single-center
Eligibility
Sex/Gender
ALL
Age
1 Years to 74 Years
Healthy volunteers
Yes
Inclusion criteria
* medically diagnosed with stenosis of larynx * patients who were observed larynx by MRI and CT * patients who need surgical treatment of stenosis of larynx
Exclusion criteria
* pregnancy * patients who has positive electromyography findings of motion of laryngeal muscles * patients who has contraindications to surgical treatment on the other diseases * patients who has not normal results of lab. analyses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline forced expiratory volume | at baseline and at 24-week postrandomization | Spirometry |
| Change from baseline area between vocal cords | at baseline and at 24-week postrandomization | MRI and CT of larynx |
| Change from basiline vocal fold vibration | at baseline and at 24-week postrandomization | Laryngoscopy and stroboscopy |
| Evaluate the motor system by recording action potential generated in muscle fibres like thyroarytenoid, lateral cricoarytenoid, posterior cricoarytenoid, interarytenoid, cricothyroid. | at baseline | Electromyography |
Countries
Kazakhstan, Russia
Contacts
Primary ContactAliya Turayeva, PhD
Outcome results
None listed