CORNEAL EPITHELIAL MAPPING IN DIABETICS

EVALUATION OF CORNEAL EPITHELIAL THICKNESS MAPPING IN DIABETIC PATIENTS USING ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY AND ITS CORRELATION TO MACULAR THICKNESS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04734158

Enrollment

153

Registered

2021-02-02

Start date

2019-08-12

Completion date

2025-12-31

Last updated

2024-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cornea Epithelial Mapping

Keywords

cornea epithelium OCT diabetes

Brief summary

The corneal epithelium is the outermost layer that covers the front of the eye; it not only functions as a barrier that blocks the passage of foreign material, but also plays an important role in maintaining high optical quality. The stem cells in the basal layer of the limbal epithelium hold a physiological significance in the renewal and metabolism of corneal epithelium, particularly under stressful situations.

Detailed description

The cornea in diabetic patients suffers from cellular dysfunction and dysfunctional repairal mechanisms, which include recurrent erosions, delayed wound healing, ulcers, and edema. In addition and undoubtedly related to epithelial dysfunction, alterations in epithelial basement membrane occur.

Interventions

OTHERcorneal imaging

corneal imaging using AS-OCT

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. The patients aged between 40- 60 years old of both genders. 2. The patients in (Group A) should be diabetics for more than 10 years and free from any other systemic diseases with diabetic macular edema (by OCT). 3. The patients in (Group B) should be diabetics for more than 10 years and free from any other systemic diseases without diabetic macular edema (by OCT). 4. The patients in (Group C) should be free of any systemic diseases and normal macular thickness (by OCT)

Exclusion criteria

1. Previous history of any intraocular surgery, intravitreal injection, laser or refractive surgery. 2. Ocular surface disorders (e.g. dry eye) or any corneal pathology. 3. Corneal scars or epithelial dystrophies. 4. Use of any topical medications. 5. Elevated IOP, pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame	Description
corneal epithelial thickness	2 years	corneal thickness in diabetics using OCT

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026