Female Infertility, Frozen-thawed Embryo Transfer, Infertility
Conditions
Keywords
infertility, female infertility, frozen- thawed embryo transfer, female
Brief summary
The purpose of this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Detailed description
For a pregnancy to occur, the embryo must implant in a receptive endometrium during the window of implantation, which is thought to occur from day 22 to 24 of an idealized 28-day cycle. Early studies have suggested that assessing endometrial thickness with the use of ultrasound may be an alternative to invasive techniques such as endometrial biopsy for attempting to determine a receptive endometrium for frozen-thawed embryo transfer (FET). A preovulatory endometrial thickness of 7 mm or more is considered to be the cutoff for endometrial receptivity, below which many physicians would cancel an embryo transfer. However, in most studies in the literature, endometrial thickness was measured either on the day of hCG in fresh embryo transfer cases or on the last day of estrogen treatment in thawed embryo transfers. There are a limited number of studies evaluating the luteal period, embryo transfer day and endometrial thickness. Accordingly, in this prospective cohort study is to assess the effect of endometrial compaction caused by progesterone effect on pregnancy outcomes
Interventions
DRUGProgesterone
ultrasound measurements of endometrial thickness at the end of the estrogen phase and the day of embryo transfer.
Sponsors
Akdeniz University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Woman aged 18-40 years 2. Presence of high quality (\>2BB) blastocyst 3. Hormonal(estrogen and progesterone) frozen- thawed embryo transfer cycles 4. presence of high quality blastocyst cryopreserved by vitrification method. 5. A single embryo transfer
Exclusion criteria
1. Presence of uterine pathology 2. Participants whose optimal endometrial image cannot be obtained due to uterine position 3. Participants whose treatments were canceled for any reason before embryo transfer 4. Participants which had embryo transfer on the day 2 or 3 (at the cleavage stage) 5. Participants who had 2 embryo transfer 6. Presence of low quality (\<2BB) blastocyst 7. \> 15% loss of viability in the embryo during embryo thawing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change in endometrial thickness | 1 year | changing in millimeters of endometrial thickness at the end of the estrogen phase and the day of embryo transfer. |
| ongoing pregnancy rates. | 1 year | pregnancy beyond 12 weeks of gestational age. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The Correlation of Serum Progesterone Levels With the Degree of Endometrial Compaction on the Day of Frozen Embryo Transfer | On the day of frozen embryo transfer | comparison of progesterone levels and endometrial thickness |
| Clinical pregnancy rate | 6-7 weeks after the last menstrual period of the patient | 6th week gestational age |
| Implantation rate | 5 weeks after the last menstrual period of the patient | Percentage of gestational sacs compared to the number of embryos transferred |
| Clinical miscarriage | after 5th gestational week | pregnancy loss after ultrasonographic detection of an intrauterine gestational sac |
Countries
Turkey (Türkiye)
Outcome results
None listed