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Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response to Filling.

Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response to Filling

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04732481
Acronym
CAROT
Enrollment
21
Registered
2021-02-01
Start date
2021-04-01
Completion date
2021-09-01
Last updated
2022-03-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Organ Failure, Multiple

Brief summary

Patients hospitalized in intensive care often require intravenous administration of fluid in order to optimize the functioning of the heart and thus ensure perfusion of vital organs such as the kidneys, the brain or the digestive tract. However, it is necessary to find the right balance in fluid intake because it has been shown that excessive administration has a negative impact on patient survival, the length of their stay in intensive care or the duration of invasive mechanical ventilation.The passive leg lifting maneuver is regularly used to determine which patients should be infused with these large volumes (the patient's chest is placed in a horizontal position and the legs are elevated at 30 ° by tilting the bed for 2 minutes ). To be interpreted, this maneuver requires the presence of invasive devices (bloody arterial pressure catheter, PICCO monitor) or an operator experienced in cardiac ultrasound.Our study aims to evaluate an easy-to-use, non-invasive tool widely available in intensive care and emergency departments (carotid vascular doppler ultrasound) to assess the response to a passive leg lifting maneuver. . The measurements are taken before and after a passive leg lifting maneuver and then before and after a filling decided before inclusion by the doctor responsible for the patient.

Interventions

PROCEDUREpassive leg lift test

passive leg lift test

Sponsors

Centre Hospitalier de Cornouaille
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* equipped with a PICCO2® continuous cardiac output monitoring device * for which the practitioner in charge of the patient decides to administer a volume expansion

Exclusion criteria

* patients whose rhythm is non-sinus * who have expressed their refusal to participate in the protocol * contraindicated to passive leg lifting maneuvers (deep vein thrombosis, HTIC, BMI\> 40 or\> 14, spinal instability) * pregnant women and patients clinically suspected of abdominal compartment syndrome

Design outcomes

Primary

MeasureTime frameDescription
response to filling90secCollection of the diagnosis of response to filling after volume expansion of 500mL of Isotonic Salted Serum and evaluation of the variation in TFCc during passive leg lifting between the two groups

Secondary

MeasureTime frameDescription
cut-off value for positivity of the test90secThe secondary objective of this work is to determine the best positivity threshold value of the test studied as well as its sensitivity and specificity for the chosen value.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026