Retinal Vascular
Conditions
Keywords
Retinal vascular density, Optical coherence tomography angiography, Choroidal thickness, Retinal nerve fiber layer thickness, Optic nerve head, Optical coherence tomography
Brief summary
Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone. Blood volume starts to increase in the first gestational period and reaches a peak in the third trimester. The physiologic ocular changes during pregnancy are mainly the result of hormonal and blood volume increase, and then are usually marked in the third trimester.
Detailed description
Ocular anterior segment changes during pregnancy are the followings * Melanogenesis of eyelid and facial skin -\> melasma * Cellular alteration of lacrimal and meibomian gland -\> dry eye symptoms * Increased corneal thickness and corneal curvature -\> contact lens intolerance * Increased lens thickness -\> loss of accommodation * Decreased intraocular pressure -\> better glaucoma control There are few studies of posterior changes in pregnant women. Many limitations of previous publications includes lack of internal control and no data of postpartum contraception. However, choroidal thickness seems to be thicker in pregnant women than non-pregnant women. The other changes are non-inclusive.
Interventions
DEVICEOptical coherence tomography and optical coherence tomography angiography (Optovue®)
Optical coherence tomography and optical coherence tomography angiography (Optovue®) were performed in each trimesters and at 6 weeks after childbirth. 1. st trimester : gestational age 8-12 weeks 2. nd trimester : gestational age 24-28 weeks 3. rd trimester : gestational age 34-38 weeks
Sponsors
Khon Kaen University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy pregnant women * Age \> 18 years * Gestational age \< 12 weeks * Written informed consent
Exclusion criteria
* High risk pregnancy such as multifetal pregnancy and preeclampsia * History of vitreoretinal diseases such as retinal vasculitis * History of intraocular laser treatments or intraocular surgeries * History of systemic diseases such as diabetes mellitus and thyroid disease * Refractive error; spherical equivalence \> 4 diopters * Clear ocular media * Could not be taken the images by non-dilated pupil Withdrawal Criteria: * Preterm labor; gestational age \< 34 weeks * Multifetal pregnancy was demonstrated by ultrasound * Severe labor and delivery complications such as * Severe postpartum complications such as postpartum bleeding * Taking hormone during the follow-up period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal vascular density | 40 weeks | % of retinal vascular density is measured by optical coherence tomography angiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Choroidal thickness | 40 weeks | Choroidal thickness (um) is measured by optical coherence tomography |
| Retinal nerve fiber layer thickness | 40 weeks | Retinal nerve fiber layer thickness (um) is measured by optical coherence tomography |
| Optic disc tomography | 40 weeks | Cup area and disc area (mm3) are measured by optical coherence tomography |
Countries
Thailand
Contacts
Primary ContactSuthasinee Sinawat, MD
Outcome results
None listed