Retinal Vascular
Conditions
Keywords
retinal vascular density, choroidal thickness, optic nerve head, optical coherence tomography, optical coherence tomography angiography, menstrual cycle
Brief summary
Changes of luteinizing hormone (LH), estrogen and progesterone during the menstrual cycle influence the ocular physiology in both anterior and posterior segments. From the literature review, there were no significant differentiation in tear physiology, anterior chamber dept, lens thickness and refractive status. Some studies demonstrated then the central corneal thickness was thinner in the follicular phase, but this is non-conclusive. Advance in ophthalmic technologies provide few studies of posterior segment changes during the menstrual cycle, however, there were quite difference in methodology such as detection methods of ovulation.
Detailed description
There were 2 studies of posterior segment changes during the menstrual cycle. Akar et al showed significant decrease of neuroretinal rim area and increase of cupt area in late luteal phase. Ulas et al found that choroidal thickness was significant thicker in mid-luteal phase. However, the study of retinal vascular density by optical coherence tomography angiography (OCTA) during the menstrual cycle has never been published before.
Interventions
DEVICEOptovue®
Optical coherence tomography and optical coherece tomography angiography
Sponsors
Khon Kaen University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Female with age 25-40 yr * Normal body mass index (18.5-24.9) * Regular menstrual cycle (28-32 days) * Written informed consent
Exclusion criteria
* Pregnant women * Lactating women * Having childbirth or miscarriage within 6 months * Systemic diseases which need taking the regular medication * History of ocular disease such as glaucoma, retinal vascular diseases and macular disease * History of hormonal taking such as oral contraceptive pills within 6 months * History of intraocular laser and intraocular surgery * Refractive error; spherical equivalent \>4 diopters * Can not taking the images by Optovue® such as spine diseases Withdrawal criteria * Pregnancy detection during the study period * Receiving sex hormone during the study period such as emergency contraceptive pills
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal vascular density | 1 month | % of retinal vascular density is measured by optical coherence tomography angiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Choroidal thickness | 1 month | Choroidal thickness (um) is measured by optical coherence tomography |
| Retinal nerve fiber layer thickness | 1 month | Retinal nerve fiber layer thickness (um) is measured by optical coherence tomography |
| Optic nerve head topography | 1 month | Disc area and cup area (mm3) are measured by optical coherence tomography |
Countries
Thailand
Contacts
Primary ContactSuthasinee Sinawat, MD
Outcome results
None listed